Table 1 Hematological values of rats treated with AT-533
From: Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Parameters | Control | Vehicle | 5 mg/kg | 50 mg/kg | 250 mg/kg a | 500 mg/kg b |
|---|---|---|---|---|---|---|
WBC (×109/L) | 10.588 ± 2.553 | 10.187 ± 2.233 | 9.951 ± 3.668 | 7.650 ± 2.673 | 8.680 ± 2.691 | 9.120 ± 4.327 |
RBC (×1012/L) | 8.669 ± 0.875 | 8.769 ± 0.723 | 8.472 ± 1.731 | 9.341 ± 1.025 | 8.650 ± 0.870 | 7.860 ± 0.212 |
HGB (g/L) | 189.500 ± 18.429 | 189.700 ± 14.213 | 210.700 ± 20.913 | 191.300 ± 23.109 | 184.600 ± 18.716 | 156.000 ± 4.243 |
HCT (%) | 54.610 ± 5.864 | 55.310 ± 3.844 | 55.922 ± 7.724 | 57.130 ± 6.898 | 55.640 ± 5.664 | 47.250 ± 3.465 |
MCV (fl) | 63.030 ± 3.447 | 63.150 ± 2.414 | 62.460 ± 2.881 | 61.160 ± 2.800 | 64.380 ± 2.509 | 60.100 ± 2.828 |
MCH (Pg) | 21.940 ± 1.947 | 21.650 ± 0.617 | 24.322 ± 5.617 | 20.490 ± 1.135 | 21.360 ± 1.139 | 19.850 ± 0.071 |
MCHC (g/L) | 348.000 ± 23.161 | 342.900 ± 7.767 | 385.556 ± 89.083 | 335.100 ± 16.549 | 331.600 ± 6.189 | 331.000 ± 15.556 |
RDW (%) | 14.550 ± 1.311 | 14.690 ± 0.915 | 17.300 ± 6.748 | 15.450 ± 1.160 | 16.740 ± 0.503 | 16.950 ± 0.071 |
PLT (×109/L) | 540.556 ± 124.175 | 520.667 ± 201.604 | 518.667 ± 116.387 | 523.222 ± 101.206 | 465.000 ± 129.524 | 933.500 ± 92.631* |
MPV (fl) | 6.110 ± 0.671 | 6.160 ± 0.747 | 6.420 ± 0.464 | 6.490 ± 0.702 | 6.700 ± 0778 | 6.100 ± 0.424 |
NE (×109/L) | 3.051 ± 1.778 | 3.103 ± 1.985 | 2.572 ± 1.171 | 2.379 ± 0.798 | 2.655 ± 0.665 | 3.030 ± 1.952 |
NE% (%) | 23.979 ± 8.502 | 29.119 ± 8.283 | 25.889 ± 5.137 | 28.728 ± 8.553 | 25.906 ± 10.537 | 31.690 ± 6.392 |
LY (×109/L) | 6.976 ± 1.805 | 7.497 ± 2.412 | 6.599 ± 2.541 | 5.955 ± 1.845* | 5.886 ± 2.056 | 5.640 ± 2.192 |
LY% (%) | 66.452 ± 11.824 | 67.747 ± 9.875 | 64.331 ± 8.608 | 65.039 ± 7.785 | 68.030 ± 11.234 | 63.265 ± 5.975 |
EO (×109/L) | 0.094 ± 0.094 | 0.050 ± 0.055 | 0.111 ± 0.083 | 0.073 ± 0.070 | 0.086 ± 0.066 | 0.035 ± 0.021 |
EO% (%) | 0.656 ± 0.598 | 0.404 ± 0.325 | 1.922 ± 2.863 | 0.842 ± 0.646 | 0.960 ± 0.622 | 0.365 ± 0.035 |
MO (×109/L) | 0.421 ± 0.136 | 0.490 ± 0.125 | 0.558 ± 0.259 | 0.393 ± 0.202 | 0.408 ± 0.243 | 0.405 ± 0.148 |
MO% (%) | 3.994 ± 0.783 | 4.537 ± 1.050 | 6.447 ± 1.589 | 5.091 ± 1.498 | 4.686 ± 1.892 | 4.550 ± 0.552 |
BA (×109/L) | 0.047 ± 0.051 | 0.015 ± 0.021 | 0.052 ± 0.044 | 0.025 ± 0.031 | 0.040 ± 0.039 | 0.010 ± 0.014 |
BA% (%) | 0.336 ± 0.343 | 0.109 ± 0.114 | 0.375 ± 0.365 | 0.298 ± 0.325 | 0.420 ± 0.375 | 0.125 ± 0.106 |