Table 2 Serum biochemical values of rats treated with AT-533
From: Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Parameters | Control | Vehicle | 5 mg/kg | 50 mg/kg | 250 mg/kg a | 500 mg/kg b |
|---|---|---|---|---|---|---|
TP (g/L) | 58.000 ± 3.357 | 59.800 ± 3.472 | 62.530 ± 6.772 | 61.000 ± 12.544 | 59.500 ± 7.093 | 60.500 ± 3.125 |
ALB (g/L) | 29.740 ± 2.068 | 30.070 ± 1.941 | 31.360 ± 3.037 | 29.270 ± 2.547 | 30.720 ± 3.118 | 29.900 ± 2.076 |
ALT (U/L) | 45.500 ± 5.297 | 44.900 ± 6.523 | 50.900 ± 13.420 | 46.700 ± 10.111 | 49.600 ± 13.667 | 58.000 ± 8.973 |
AST (U/L) | 115.800 ± 25.271 | 112.400 ± 43.958 | 138.700 ± 45.078 | 123.200 ± 38.557 | 140.600 ± 116.223 | 157.000 ± 57.865 |
T-Bil (µmol/L) | 0.475 ± 0.213 | 0.360 ± 0.111 | 0.334 ± 0.199 | 0.280 ± 0.163 | 0.224 ± 0.106 | 0.170 ± 0.132 |
D-Bil (µmol/L) | 0.097 ± 0.070 | 0.069 ± 0.047 | 0.053 ± 0.052 | 0.032 ± 0.033 | 0.032 ± 0.038 | 0.020 ± 0.048 |
I-Bil (µmol/L) | 0.378 ± 0.176 | 0.291 ± 0.103 | 0.281 ± 0.171 | 0.248 ± 0.141 | 0.192 ± 0.095 | 0.150 ± 0.098 |
ALP (U/L) | 228.100 ± 68.286 | 227.700 ± 78.370 | 245.100 ± 62.413 | 237.800 ± 75.889 | 329.400 ± 71.835* | 343.000 ± 78.632* |
BUN (µmol/L) | 5.053 ± 1.422 | 5.342 ± 0.966 | 4.671 ± 1.175 | 4.810 ± 1.341 | 4.218 ± 1.187 | 6.370 ± 1.849 |
CRE (µmol/L) | 33.900 ± 10.316 | 32.940 ± 5.257 | 29.170 ± 4.454 | 25.440 ± 5.071 | 25.880 ± 9.472 | 19.800 ± 6.832 |
UA (µmol/L) | 74.590 ± 24.449 | 66.960 ± 27.964 | 105.640 ± 34.507 | 113.690 ± 71.735 | 101.920 ± 44.647 | 71.800 ± 56.820 |
GLU (µmol/L) | 12.000 ± 2.939 | 12.279 ± 3.115 | 10.993 ± 2.663 | 11.251 ± 3.348 | 11.880 ± 2.781 | 9.660 ± 3.071 |
TG (µmol/L) | 1.099 ± 0.628 | 1.126 ± 0.563 | 1.540 ± 0.639 | 1.527 ± 0.508 | 1.798 ± 0.570 | 1.730 ± 0.548 |
CHO (µmol/L) | 1.711 ± 0.186 | 1.726 ± 0.094 | 1.717 ± 0.205 | 1.536 ± 0.186 | 1.798 ± 0.264 | 2.140 ± 0.234* |
HDL (µmol/L) | 0.592 ± 0.104 | 0.627 ± 0.062 | 0.635 ± 0.092 | 0.575 ± 0.077 | 0.716 ± 0.113* | 0.900 ± 0.124** |
LDL (µmol/L) | 0.201 ± 0.056 | 0.190 ± 0.045 | 0.203 ± 0.038 | 0.186 ± 0.028 | 0.210 ± 0.025 | 0.240 ± 0.051 |
K+ (µmol/L) | 5.145 ± 0.814 | 5.000 ± 0.804 | 5.742 ± 0.623 | 5.344 ± 0.924 | 5.842 ± 0.830 | 6.790 ± 0.649* |
Na+ (µmol/L) | 142.640 ± 5.994 | 143.590 ± 4.939 | 143.040 ± 6.563 | 139.590 ± 8.788 | 144.320 ± 3.648 | 147.100 ± 6.320 |
Cl− (µmol/L) | 109.970 ± 4.028 | 111.400 ± 3.722 | 110.410 ± 4.456 | 108.420 ± 6.696 | 111.340 ± 1.278 | 111.900 ± 3.451 |