Table 3 Hematological values of rats treated with single dose of AT-533 gel (5 g/kg)
From: Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Parameters | Control | Blank gel | AT-533 gel |
|---|---|---|---|
WBC (×109/L) | 6.160 ± 1.500 | 5.931 ± 0.750 | 7.408 ± 1.684 |
RBC (×1012/L) | 8.354 ± 0.827 | 7.528 ± 1.430 | 7.533 ± 0.428 |
HGB (g/L) | 191.800 ± 25.793 | 164.889 ± 22.713 | 154.000 ± 10.149 |
HCT (%) | 52.630 ± 6.193 | 46.420 ± 8.394 | 47.133 ± 2.687 |
MCV (fl.) | 62.920 ± 2.347 | 61.770 ± 2.601 | 62.578 ± 1.150 |
MCH (Pg) | 22.920 ± 1.202 | 20.950 ± 1.216 | 20.456 ± 0.637 |
MCHC (g/L) | 364.000 ± 10.914 | 339.000 ± 13.556 | 326.778 ± 8.318 |
RDW (%) | 14.930 ± 0.750 | 14.380 ± 1.181 | 14.689 ± 0.810 |
PLT (×109/L) | 512.400 ± 161.892 | 682.000 ± 108.510 | 702.000 ± 126.206 |
MPV (f.) | 6.030 ± 0.855 | 6.150 ± 1.086 | 6.544 ± 1.099 |
NE (×109/L) | 2.229 ± 1.201 | 1.073 ± 0.526 | 1.951 ± 0.746 |
NE% (%) | 28.861 ± 7.637 | 21.924 ± 6.882 | 26.866 ± 6.016 |
LY (×109/L) | 3.934 ± 1.161 | 3.610 ± 1.359 | 5.219 ± 1.153 |
LY% (%) | 64.729 ± 6.967 | 72.214 ± 9.844 | 68.831 ± 9.050 |
EO (×109/L) | 0.139 ± 0.301 | 0.096 ± 0.234 | 0.069 ± 0.100 |
EO% (%) | 0.697 ± 0.460 | 0.936 ± 0.816 | 1.368 ± 1.989 |
MO (×109/L) | 0.442 ± 0.334 | 0.143 ± 0.078 | 0.246 ± 0.311 |
MO% (%) | 4.890 ± 1.118 | 3.042 ± 1.436 | 2.308 ± 1.112 |
BA (×109/L) | 0.070 ± 0.139 | 0.040 ± 0.109 | 0.097 ± 0.203 |
BA% (%) | 0.513 ± 0.551 | 0.256 ± 0.372 | 0.627 ± 0.951 |