Table 4 Serum biochemical values of rats treated with AT-533 single dose of AT-533 gel (5 g/kg)
From: Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Parameters | Control | Blank gel | AT-533 gel |
|---|---|---|---|
TP (g/L) | 65.110 ± 3.629 | 62.840 ± 3.208 | 65.360 ± 3.570 |
ALB (g/L) | 32.040 ± 1.247 | 30.510 ± 1.639 | 31.450 ± 2.169 |
ALT (U/L) | 73.900 ± 23.718 | 72.111 ± 19.154 | 62.000 ± 15.452 |
AST (U/L) | 106.900 ± 15.638 | 105.600 ± 21.418 | 112.400 ± 24.218 |
T-Bil (µmol/L) | 0.638 ± 0.218 | 0.565 ± 0.270 | 0.421 ± 0.145 |
D-Bil (µmol/L) | 0.105 ± 0.076 | 0.097 ± 0.083 | 0.057 ± 0.028 |
I-Bil (µmol/L) | 0.533 ± 0.215 | 0.468 ± 0.213 | 0.364 ± 0.130 |
ALP (U/L) | 180.400 ± 77.090 | 175.200 ± 79.790 | 182.000 ± 91.160 |
BUN (µmol/L) | 6.591 ± 1.385 | 5.898 ± 0.934 | 7.420 ± 1.456 |
CRE (µmol/L) | 37.220 ± 11.925 | 35.470 ± 8.359 | 40.410 ± 11.635 |
UA (µmol/L) | 57.613 ± 15.744 | 73.770 ± 31.754 | 82.540 ± 29.092 |
GLU (µmol/L) | 5.557 ± 1.327 | 7.890 ± 1.306 | 6.525 ± 1.395 |
TG (µmol/L) | 0.618 ± 0.319 | 0.630 ± 0.345 | 0.487 ± 0.188 |
CHO (µmol/L) | 1.586 ± 0.273 | 1.507 ± 0.258 | 1.333 ± 0.157 |
HDL (µmol/L) | 0.402 ± 0.132 | 0.366 ± 0.053 | 0.334 ± 0.045 |
LDL (µmol/L) | 0.124 ± 0.026 | 0.115 ± 0.027 | 0.099 ± 0.017 |
K+ (µmol/L) | 4.717 ± 0.813 | 4.601 ± 1.058 | 4.613 ± 0.914 |
Na+ (µmol/L) | 144.760 ± 1.279 | 147.770 ± 9.487 | 148.380 ± 6.093 |
Cl− (µmol/L) | 111.940 ± 2.641 | 115.930 ± 7.853 | 115.200 ± 4.934 |