Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats

Table 5 Absolute and relative weights of organs of female rats treated with AT-533

Parameters	Control	Vehicle	5 mg/kg	50 mg/kg	250 mg/kg ^a	500 mg/kg ^a
Body weight (g)	242.82 ± 16.84	250.08 ± 29.75	241.5 ± 16.07	231.62 ± 6.51	225.7 ± 0.01	207.2 ± 0.001^*
Brain	1.914 ± 0.082	1.871 ± 0.122	1.840 ± 0.073	1.860 ± 0.049	1.610 ± 0.001^**	1.810 ± 0.001
Heart	0.917 ± 0.048	0.949 ± 0.151	0.938 ± 0.063	0.713 ± 0.399	0.990 ± 0.001	0.810 ± 0.001
Liver	8.196 ± 0.599	8.636 ± 1.245	8.668 ± 0.806	8.434 ± 0.601	9.580 ± 0.001	8.750 ± 0.001
Spleen	0.505 ± 0.072	0.568 ± 0.113	0.652 ± 0.113	0.548 ± 0.043	0.600 ± 0.001	0.500 ± 0.001
Lung	1.266 ± 0.132	1.249 ± 0.133	1.136 ± 0.104	1.266 ± 0.177	1.240 ± 0.001	0.990 ± 0.001
Kidneys	1.704 ± 0.159	1.507 ± 0.230	1.604 ± 0.260	1.622 ± 0.107	2.070 ± 0.001^**	1.730 ± 0.001
Organ-to-body weight ratio (%)
Brain	0.789 ± 0.020	0.753 ± 0.051	0.764 ± 0.040	0.803 ± 0.021	0.713 ± 0.001	0.874 ± 0.001^**
Heart	0.378 ± 0.008	0.378 ± 0.026	0.389 ± 0.019	0.307 ± 0.171	0.439 ± 0.001	0.391 ± 0.001
Liver	3.377 ± 0.157	3.449 ± 0.174	3.590 ± 0.252	3.646 ± 0.327	4.245 ± 0.001^**	4.223 ± 0.001^**
Spleen	0.208 ± 0.024	0.227 ± 0.036	0.269 ± 0.037	0.237 ± 0.020	0.266 ± 0.001	0.241 ± 0.001
Lung	0.522 ± 0.054	0.501 ± 0.039	0.470 ± 0.024	0.549 ± 0.094	0.549 ± 0.001	0.478 ± 0.001
Kidneys	0.701 ± 0.029	0.602 ± 0.039	0.663 ± 0.092	0.700 ± 0.035	0.917 ± 0.001^***	0.835 ± 0.001^***

Values are mean ± SD for 5 rats in each group, ^a Data from 1 rat. * Statistically significant compared to vehicle (p < 0.05), ** Statistically significant compared to vehicle (p < 0.01), ***Statistically significant compared to vehicle (p < 0.001)

ISSN: 2050-6511