Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats

Table 6 Absolute and relative weights of organs of male rats treated with AT-533

Parameters	Control	Vehicle	5 mg/kg	50 mg/kg	250 mg/kg ^a	500 mg/kg ^b
Body weight (g)	376.660 ± 46.935	346.760 ± 14.186	342.340 ± 19.132	321.180 ± 15.806	309.425 ± 26.230	291.800 ± 0.001
Brain	2.005 ± 0.065	1.950 ± 0.116	1.966 ± 0.041	1.984 ± 0.063	1.943 ± 0.052	2.042 ± 0.001
Heart	1.358 ± 0.153	1.251 ± 0.095	1.170 ± 0.104	1.096 ± 0.024	1.165 ± 0.159	1.107 ± 0.001
Liver	12.047 ± 2.594	12.364 ± 0.752	11.922 ± 1.012	11.408 ± 0.867	11.340 ± 0.804	11.816 ± 0.001
Spleen	0.801 ± 0.127	0.764 ± 0.064	0.757 ± 0.210	0.636 ± 0.048	0.719 ± 0.144	0.749 ± 0.001
Lung	1.640 ± 0.137	1.362 ± 0.113	1.577 ± 0.162	1.398 ± 0.196	1.453 ± 0.140	1.836 ± 0.001^**
Kidneys	2.018 ± 0.530	2.316 ± 0.213	2.053 ± 0.120	2.004 ± 0.216	2.161 ± 0.231	1.824 ± 0.001
Organ-to-body weight ratio (%)
Brain	0.538 ± 0.063	0.563 ± 0.030	0.575 ± 0.030	0.619 ± 0.039	0.631 ± 0.055	0.700 ± 0.001^**
Heart	0.362 ± 0.036	0.361 ± 0.030	0.342 ± 0.023	0.342 ± 0.018	0.376 ± 0.032	0.379 ± 0.001
Liver	3.184 ± 0.453	3.565 ± 0.138	3.481 ± 0.201	3.550 ± 0.168	3.673 ± 0.231	4.049 ± 0.001
Spleen	0.215 ± 0.042	0.220 ± 0.014	0.221 ± 0.059	0.198 ± 0.014	0.231 ± 0.034	0.257 ± 0.001
Lung	0.438 ± 0.035	0.394 ± 0.045	0.461 ± 0.050	0.435 ± 0.053	0.471 ± 0.041	0.629 ± 0.001^***
Kidneys	0.533 ± 0.115	0.667 ± 0.046	0.600 ± 0.026	0.623 ± 0.041	0.698 ± 0.039	0.625 ± 0.01

Values are mean ± SD for 5 rats in each group, ^a Data from 4 rats, ^b Data from 1 rat. * Statistically significant compared to vehicle (p < 0.05), ** Statistically significant compared to vehicle (p < 0.01), ***Statistically significant compared to vehicle (p < 0.001)

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