Table 8 Absolute and relative weights of organs of male rats treated with AT-533 gel
From: Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Parameters | Control | Blank gel | AT-533 gel |
|---|---|---|---|
Body weight (g) | 298.940 ± 27.022 | 301.760 ± 13.803 | 290.060 ± 19.059 |
Brain | 1.974 ± 0.079 | 1.914 ± 0.065 | 1.754 ± 0.191 |
Heart | 1.217 ± 0.092 | 1.283 ± 0.125 | 1.172 ± 0.149 |
Liver | 8.600 ± 1.072 | 8.400 ± 0.516 | 8.036 ± 0.906 |
Spleen | 0.678 ± 0.120 | 0.641 ± 0.164 | 0.576 ± 0.087 |
Lung | 1.387 ± 0.079 | 1.363 ± 0.083 | 1.344 ± 0.134 |
Kidneys | 2.309 ± 0.155 | 2.200 ± 0.188 | 2.114 ± 0.210 |
Organ-to-body weight ratio (%) | |||
Brain | 0.664 ± 0.058 | 0.636 ± 0.046 | 0.610 ± 0.103 |
Heart | 0.408 ± 0.016 | 0.427 ± 0.057 | 0.403 ± 0.033 |
Liver | 2.874 ± 0.212 | 2.785 ± 0.150 | 2.764 ± 0.150 |
Spleen | 0.226 ± 0.025 | 0.211 ± 0.045 | 0.198 ± 0.020 |
Lung | 0.467 ± 0.049 | 0.452 ± 0.018 | 0.465 ± 0.054 |
Kidneys | 0.776 ± 0.062 | 0.729 ± 0.052 | 0.729 ± 0.053 |