Parameter | Units | Proestrus | Estrus | Metestrus | Diestrus | OVX | Male | CST |
---|---|---|---|---|---|---|---|---|
AUC | mg*min/mL | 89 ± 16.8 | 93 ± 18.3 | 108 ± 16.3 | 129 ± 16.8 | 120 ± 35.5 | 115 ± 21.6 | 116 ± 17.1 |
CL | mL/min/kg | 6.8 ± 2.6 | 6.7 ± 2.5 | 5.6 ± 2.1 | 4.7 ± 1.8 | 5.3 ± 2.1 | 5.4 ± 2.1 | 5.3 ± 2.1 |
CLR | mL/min/kg | 3.7 ± 0.4 | 3.3 ± 0.09 | 2.6 ± 0.3 | 1.9 ± 0.7*# | 1.9 ± 1.1*# | 2.0 ± 1.0* | 2.1 ± 0.8* |
fe |  | 0.54 ± 0.03 | 0.49 ± 0.09 | 0.47 ± 0.05 | 0.40 ± 0.07 | 0.36 ± 0.1* | 0.38 ± 0.06 | 0.39 ± 0.03 |
CLm | mL/min/kg | 3.1 ± 0.4 | 3.4 ± 0.7 | 3.0 ± 0.6 | 2.9 ± 0.6 | 3.4 ± 1.1 | 3.4 ± 1.1 | 3.2 ± 0.5 |