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Featured article: Preventing angiogenesis inhibits oral cancer growth

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Angiogenesis, the formation of new blood vessels from preexisting vessels, is critical for oral cancer development. Semaforin-3 (Sema3) is a secreted protein that prevents angiogenesis. Overexpression of Sema3 in oral tumor cell lines decreases tumor vasculature in vitro and decreases the size and capillary density of tumors in xenograft models of oral cancer in mice.

Featured collection: Neurometals

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Metals have many essential functions in the brain and a large body of evidence supports important roles for altered metal stasis in many brain disorders. This article collection guest edited by Section Editor, Dr Michael Aschner provides a node for other researchers across diverse fields to access brain metal research and integrate this into their own programs.

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Research article

Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine

Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V. Radonjić and Nataša Petronijević

Published on: 11 October 2017
Meeting abstracts

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

G. Todd Milne, Peter Sandner, Kathleen A. Lincoln, Paul C. Harrison, Hongxing Chen, Hong Wang, Holly Clifford, Hu Sheng Qian, Diane Wong, Chris Sarko, Ryan Fryer, Jeremy Richman, Glenn A. Reinhart, Carine M. Boustany, Steven S. Pullen, Henriette Andresen…

Published on: 10 October 2017
Research article

Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

Scott M. Belcher, Caleb C. Burton, Clifford J. Cookman, Michelle Kirby, Gabriel L. Miranda, Fatima O. Saeed and Kathleen E. Wray

Published on: 6 September 2017
Research article

Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation

Yun Hyi Ku, Bong-Jun Cho, Min Joo Kim, Soo Lim, Young Joo Park, Hak C. Jang and Sung Hee Choi

Published on: 30 August 2017
Research article

Short-term treatment with taurolidine is associated with liver injury

René Fahrner, Anika Möller, Adrian T. Press, Andreas Kortgen, Michael Kiehntopf, Falk Rauchfuss, Utz Settmacher and Alexander S. Mosig

Published on: 11 August 2017

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Review

A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study

Suzanne Dunne, Bill Shannon, Colum Dunne and Walter Cullen

Published on: 5 January 2013
Case report

Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature

Maria AP Martins, Adriano MM Reis, Mariana F Sales, Vandack Nobre, Daniel D Ribeiro, Manoel OC Rocha and Antônio LP Ribeiro

Published on: 4 May 2013
Research article

Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men

Brian K Schilling, Kelley G Hammond, Richard J Bloomer, Chaela S Presley and Charles R Yates

Published on: 4 October 2013
Research article

Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa®

Urs E Gasser, Anton Fischer, Jan P Timmermans and Isabelle Arnet

Published on: 23 April 2013
Research article

Comparing antibiotic self-medication in two socio-economic groups in Guatemala City: a descriptive cross-sectional study

Brooke M Ramay, Paola Lambour and Alejandro Cerón

Published on: 27 April 2015

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Aims and scope

BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials.It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.

Editor

Benjamin Ragen, BioMed Central

Section Editors

Michael Aschner, Albert Einstein College of Medicine
Phil Biggin, University of Oxford
Lucio Guido Costa, University of Washington
David H Farb, Boston University School of Medicine
Giorgio Palu, University of Padova
Catherine MT Sherwin, University of Utah

Catherine Sherwin, Section Editor

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Dr. Catherine Sherwin is currently an Associate Professor

Meet our Section Editors

Data support service

Authors submitting to this journal can opt to use a new service that will make it easier to share research data.

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BMC Pharmacology

BMC Pharmacology and Toxicology assimilated the Editorial boards and history of BMC Pharmacology and BMC Clinical Pharmacology on fusion of the journals in 2012. The full archive of BMC Pharmacology is available from its own archive website, and the objectives and aspirations of the merged journal are explained in the editorial that accompanied the fusion. The full archive of BMC Clinical Pharmacology is available here.

BMC Series blog

11th International Conference on Behavior, Physiology and Genetics of Wildlife

Published on: 13 October 2017
A hazardous undertaking: how ant queens prevent disease during colony foundation

Published on: 13 October 2017
World Food Day 2017: investing in food security and rural development

Published on: 13 October 2017

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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