Skip to main content

Articles

Page 1 of 25

  1. Numerous digestive system adverse events (dsAEs) have been observed during the use of anti-obesity medications (AOMs), leading to concerns about the safety of these medications. However, most current studies a...

    Authors: Qing Yang, Junyan Wang, Menghuan Wang, Shuyu Zhang and Qin-Qin He
    Citation: BMC Pharmacology and Toxicology 2024 25:64
    Content type: Research Published on:

  2. The impact of Sodium Houttuyniae (SH) on lipopolysaccharide (LPS)-induced ALI has been investigated extensively. However, it remains ambiguous whether ferroptosis participates in this process. This study aimed...

    Authors: Juan Li, Yan-ping Hu, Xing-ling Liang and Ming-wei Liu
    Citation: BMC Pharmacology and Toxicology 2024 25:63
    Content type: Research Published on:

  3. Higher olefins (HO) are a category of unsaturated hydrocarbons widely used in industry applications to make products essential for daily human life. Establishing safe exposure limits requires a solid data matr...

    Authors: Quan Shi, Michael G. Penman, Juan-Carlos Carrillo, An R. Van Rompay, Lenny Kamelia, Martijn Rooseboom, Hua Shen, Sophie Jia, Yuan Tian, Jamie Dunn, Fabienne Hubert and Peter J. Boogaard
    Citation: BMC Pharmacology and Toxicology 2024 25:62
    Content type: Research Published on:

  5. Triazolam is a typical drug commonly used in the elderly; however, there have been concerns about its adverse events resulting from age-related changes in physiological function and drug interactions with conc...

    Authors: Akira Okada, Shoji Sera and Naomi Nagai
    Citation: BMC Pharmacology and Toxicology 2024 25:60
    Content type: Research Published on:

  6. Recent studies have shown that liver enzyme abnormalities were not only seen with typical antipsychotics (APs) but also with atypical antipsychotics (AAPs). During the last 20 years, the hepatotoxicity of vari...

    Authors: Sidi He, Bin Chen and Chuanwei Li
    Citation: BMC Pharmacology and Toxicology 2024 25:59
    Content type: Research Published on:

  7. We aim to explore the association between NSAIDs consumption, Symptomatic Slow Action Drugs for Osteoarthritis (SYSADOA), analgesics, and antiplatelet drugs, and decline in renal function by estimated Glomerul...

    Authors: Sara Bonet-Monné, Cristina Vedia Urgell, M. José Pérez Sáez, Oriol Cunillera Puertolás, José Miguel Baena-Díez, Julio Pascual, Cristina Orive Lago, Jordi Rodriguez Ruiz, Betlem Salvador Gonzalez and Rosa Morros Pedrós
    Citation: BMC Pharmacology and Toxicology 2024 25:58
    Content type: Research Published on:

  8. Febuxostat is commonly used in clinic for the treatment of hyperuricemia. Multiple-peak phenomenon has been observed in human plasma concentration-time profiles of febuxostat, but has not been paid enough atte...

    Authors: Wenjun Chen, Bo Jiang, Zourong Ruan, Dandan Yang, Yin Hu and Honggang Lou
    Citation: BMC Pharmacology and Toxicology 2024 25:57
    Content type: Research Published on:

  9. Direct oral anticoagulants (DOACs) have high potency against their therapeutic target and are widely used in the treatment of atrial fibrillation (AF). Most DOACs are often claimed to have adverse effects due ...

    Authors: M. Sudhan, V. Janakiraman, Sheikh F. Ahmad, Sabry M. Attia, Ramasamy Subramanian, Durga Devi and Shiek S. S. J. Ahmed
    Citation: BMC Pharmacology and Toxicology 2024 25:56
    Content type: Research Published on:

  10. Metamizole is banned in some countries because of its toxicity, although it is widely used in some European countries. In addition, there is limited information on its safety profile, and it is still debated w...

    Authors: Sedat Ciftel, Bahadir Suleyman, Renad Mammadov, Resit Coskun, Taha A. Coban, Behzad Mokhtare, Halis Suleyman, Serkan Cerrah, Betul Cicek and Zeynep Suleyman
    Citation: BMC Pharmacology and Toxicology 2024 25:55
    Content type: Research Published on:

  12. Econazole is a widely used imidazole derivative antifungal for treating skin infections. The molecular targets for its frequent adverse effects of skin irritation symptoms, such as pruritus, burning sensation,...

    Authors: Kaoru Kasuya, Kenji Takahashi, Miho Hashimoto and Toshio Ohta
    Citation: BMC Pharmacology and Toxicology 2024 25:53
    Content type: Research Published on:

  13. An increasing body of research implicates inflammatory processes, including alterations in the neutrophil-lymphocyte ratio (NLR), in the pathophysiology of psychiatric illness. The deer mouse (Peromyscus manicula...

    Authors: J.P. Strydom, Linda Brand, Francois P. Viljoen and De Wet Wolmarans
    Citation: BMC Pharmacology and Toxicology 2024 25:52
    Content type: Research Published on:

  14. Fluoxetine is present in breast milk, yet it is unclear to what extent it, or its active metabolite, norfluoxetine, reaches the brain of the infant and what the effects of such exposure on neurobiological proc...

    Authors: Stephan F. Steyn, Malie Rheeders, Francois P. Viljoen and Linda Brand
    Citation: BMC Pharmacology and Toxicology 2024 25:51
    Content type: Research Published on:

  15. This study reports a novel, eco-friendly; fast and cost-effective microwave method for synthesizing carboxymethylated graphene oxide (CMGO) from sugarcane residues. Fourier-transform infrared spectroscopy (FTI...

    Authors: Hebat-Allah S. Tohamy, Fatma El-Zahraa S. Mohamed and Mohamed El-Sakhawy
    Citation: BMC Pharmacology and Toxicology 2024 25:50
    Content type: Research Published on:

  16. This study aims to comprehensively assess the safety of Asenapine by conducting an comprehensive statistical analysis of adverse event reports in the FAERS database, with a particular focus on potential advers...

    Authors: Liuyin Jin, Jiali Gu, Yun Wu, Hua Xia, Guoming Xie and Guidong Zhu
    Citation: BMC Pharmacology and Toxicology 2024 25:49
    Content type: Research Published on:

  17. Addressing critical veterinary drugs, especially drugs with solubility problems like albendazole, and their implications for therapeutic efficacy, in-vitro dissolution studies can indeed provide valuable insig...

    Authors: Yesuneh Tefera Mekasha, Abibo Wondie Mekonen, Sete Nigussie, Rashed Edris Usure and Melaku Getahun Feleke
    Citation: BMC Pharmacology and Toxicology 2024 25:48
    Content type: Research Published on:

  18. Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors marked a milestone in the breast cancer treatment. Due to the potential impact of adverse effects on treatment decisions and patient outcomes, careful considerat...

    Authors: Wanlong Lin, Yanbin Zeng, Lizhu Weng, Jianhui Yang and Wei Zhuang
    Citation: BMC Pharmacology and Toxicology 2024 25:47
    Content type: Research Published on:

  19. Echis ocellatus envenoming is potentially toxic initiating clinical damages on male reproductive system. Kaempferol is a therapeutic agent with neutralizing potentials on snake venom toxins. This study investigat...

    Authors: Babafemi Siji Ajisebiola, Adesola Abigeal Toromade, Johnson Olaleye Oladele, Abdur-Rahman Kolawole Mustapha, Olukunle Silas Fagbenro and Akindele Oluwatosin Adeyi
    Citation: BMC Pharmacology and Toxicology 2024 25:46
    Content type: Research Published on:

  20. Concentrations of metoprolol in exhaled breath condensate (EBC) have not been investigated. Herein, we aim to determine the metoprolol levels in EBC, plasma, and urine samples.

    Authors: Jalil Houshyar, Nastaran Hashemzadeh, Maryam Khoubnasabjafari, Amirreza Jabbaripour Sarmadian, Vahid Jouyban-Gharamaleki, Mohammad Reza Afshar Mogaddam, Elnaz Marzi Khosrowshahi and Abolghasem Jouyban
    Citation: BMC Pharmacology and Toxicology 2024 25:45
    Content type: Research Published on:

  21. Colorectal cancer (CRC), now the second most prevalent malignant tumor worldwide, is more prevalent in young adults. In recent decades, there has been progress in creating anti-colorectal cancer medications, i...

    Authors: Tohid Piri-Gharaghie, Hedieh Ghourchian, Golnoosh Rezaeizadeh, Hamidreza Kabiri, Negin Rajaei, Aya Mohammed Dhiaa, Ghazal Ghajari and Roghayeh Bahari
    Citation: BMC Pharmacology and Toxicology 2024 25:44
    Content type: Research Published on:

  22. Endometriosis and adenomyosis are two common diseases that impair women’s health, and dienogest is one of the pharmacologic treatments which is the first-line therapeutic option for patients with pelvic pain a...

    Authors: Rui-Rui Li, Qing Xi, Lei Tao, Wei Sheng, Cheng-Cheng Zhao and Yu-Jie Wu
    Citation: BMC Pharmacology and Toxicology 2024 25:43
    Content type: Systematic Review Published on:

  23. A global increase in cannabis use has led to questions about its effects on fertility. The rise in consumption amongst women of reproductive age is a growing concern, as this group is vulnerable in terms of re...

    Authors: Sabrina Floccari, Reem Sabry, Laurie Choux, Michael S. Neal, Jibran Y. Khokhar and Laura A. Favetta
    Citation: BMC Pharmacology and Toxicology 2024 25:42
    Content type: Research Published on:

  24. The use of cefoperazone/sulbactam (CPZ/SAM) could commonly cause vitamin K-dependent coagulation disorders and even hemorrhage sometimes. However, there is a lack of prediction tools estimating the risk for th...

    Authors: An Fu, Feng Ge, Yanwei Wang, Haili Guo, Man Zhu, Shu Li, Ao Gao, Chao Li, Jingchuan Lu and Daihong Guo
    Citation: BMC Pharmacology and Toxicology 2024 25:41
    Content type: Research Published on:

  25. Periapical lesions are characterized by periapical inflammation and damage to periapical tissues and eventually lead to bone resorption and even tooth loss. H2O2 is widely used in root canal therapy for patients ...

    Authors: Zhengjun Peng, Wenyu Zhang, Hong Hong and Lu Liu
    Citation: BMC Pharmacology and Toxicology 2024 25:40
    Content type: Research Published on:

  27. Dihydroartemisinin-piperaquine (DHP) recently showed superior effectiveness over sulfadoxine-pyrimethamine for malaria intermittent preventive treatment in pregnancy (IPTp). We investigated day 7 piperaquine p...

    Authors: Eulambius M. Mlugu, Omary M.S. Minzi, Mats Johansson, Appolinary A. R. Kamuhabwa and Eleni Aklillu
    Citation: BMC Pharmacology and Toxicology 2024 25:38
    Content type: Research Published on:

  28. We investigated acute poisonings resulting from medications affecting the nervous system and illicit substances at Loghman Hakim Hospital in Tehran.

    Authors: Bita Mesgarpour, Shabnam Faridfar, Mahya Rezaei, Akbar Abdollahiasl, Shahin Shadnia, Arezou Mahdavinejad and Mohammad Abdollahi
    Citation: BMC Pharmacology and Toxicology 2024 25:37
    Content type: Research Published on:

  29. Chalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13 chalcones were designed with the inspiration of Loureirin, a ...

    Authors: Peng Li, Xiangjuan Tian, Die Zhang, Huiping Ou, Qiufeng Huang, Wenbin Jin and Ran Liu
    Citation: BMC Pharmacology and Toxicology 2024 25:36
    Content type: Research Published on:

  30. It is unclear whether the parent Saxagliptin (SAX) in vivo is the same as that in vitro, which is twice that of 5-hydroxy Saxagliptin (5-OH SAX). This study is to construct a Pharmacokinetic-Pharmacodynamic (P...

    Authors: Tianyan Wang, Ting Tao, Yi Liu, Jie Dong, Shanhong Ni, Yun Liu, Yanli Li, Ning Xu and Zengxian Sun
    Citation: BMC Pharmacology and Toxicology 2024 25:35
    Content type: Research Published on:

  31. Antiplatelet therapy is an important factor influencing the postterm patency rate of carotid artery stenting (CAS). Clopidogrel is a platelet aggregation inhibitor mediated by the adenosine diphosphate recepto...

    Authors: Pengfei Li, Mengying Cao, Ling Liu, Long Chen, Shuang Liang and Youbin Wang
    Citation: BMC Pharmacology and Toxicology 2024 25:34
    Content type: Research Published on:

  32. The specific mechanism by which rotenone impacts thoracic aortic autophagy and apoptosis is unknown. We aimed to investigate the regulatory effects of rotenone on autophagy and apoptosis in rat thoracic aortic...

    Authors: Xiaoyu Chang, Zeyuan Li, Mi Tian, Ziwei Deng, Lingqin Zhu and Guanghua Li
    Citation: BMC Pharmacology and Toxicology 2024 25:33
    Content type: Research Published on:

  33. Pruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta hydroxy-γ-tri methyl amino-butyric acid), is a naturally occurring substance, it c...

    Authors: Kiran Seemab, Arif-ullah Khan, Muhammad Imran Khan, Neelum Gul Qazi, Amber Mahmood Minhas and Fawad Ali
    Citation: BMC Pharmacology and Toxicology 2024 25:32
    Content type: Research Published on:

  34. In the current work, favipiravir (an antiviral drug) loaded pH-responsive polymeric hydrogels were developed by the free redical polymerization technique. Box-Behnken design method via Design Expert version 11...

    Authors: Arooj Khan, Muhammad Zaman, Muhammad Ahsan Waqar, Asif Mahmood, Talal Shaheer, Rai Muhammad Sarfraz, Kanwal Shahzadi, Azmat Ali Khan, Amer M. Alanazi, Milton Kumar Kundu, Md Rabiul Islam, Athanasios Alexiou and Marios Papadakis
    Citation: BMC Pharmacology and Toxicology 2024 25:31
    Content type: Research Published on:

  35. Calycosin, a flavonoid compound extracted from Astragalus membranaceus, has shown anti-asthma benefits in house dust mite-induced asthma. Recent studies have suggested that innate-type cells, including group 2 in...

    Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang and Zhuying Li
    Citation: BMC Pharmacology and Toxicology 2024 25:30
    Content type: Research Published on:

  36. Monoclonal antibody therapy for Covid-19 springs up all over the world and get some efficiency. This research aims to explore the treating effect of BRII-196(Ambavirumab) plus BRII-198(Lomisivir) on Covid-19.

    Authors: Qin Yalan, Hao Lingfang, Liu Xisong, Liang Run, Zhang Junjing and Zhang’ An
    Citation: BMC Pharmacology and Toxicology 2024 25:29
    Content type: Research Published on:

  37. Dialysis patients are at high risk for drug-related problems (DRPs), which have significant consequences for their morbidity, mortality, and quality of life. Improved clinical outcomes can be achieved by preve...

    Authors: Aysel Pehlivanli, Sayeste Akkan Eren, Sule Sengul, Bilgen Basgut, Sehsuvar Erturk and A. Tanju Ozcelikay
    Citation: BMC Pharmacology and Toxicology 2024 25:28
    Content type: Research Published on:

  38. Nicotine, the main compound of smoking may exert its effects by changing the expression of microRNAs (miRNAs). This study was conducted to further investigate the molecular mechanisms of miRNA-dependent effect...

    Authors: Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi-Sales and Mohammad Reza Alipour
    Citation: BMC Pharmacology and Toxicology 2024 25:27
    Content type: Research Published on:

  39. Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Dapagliflozin is widely used in the treatment of type 2 diabete...

    Authors: Lin Xiang, Min Liu, Guangda Xiang, Ling Yue, Junxia Zhang, Xiaoli Xu and Jing Dong
    Citation: BMC Pharmacology and Toxicology 2024 25:26
    Content type: Research Published on:

  40. It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunologic...

    Authors: Tove Selvin, Malin Berglund, Lena Lenhammar, Magnus Lindskog, Malin Jarvius, Rolf Larsson, Peter Nygren, Mårten Fryknäs and Claes R Andersson
    Citation: BMC Pharmacology and Toxicology 2024 25:25
    Content type: Research Published on:

  41. This study aimed to evaluate the long-term risk of CKD and renal function declines using a combination of diuretics and SGLT2i.

    Authors: Han-Jie Lin, Pin-Yang Shih, Stella Chin-Shaw Tsai, Wu-Lung Chuang, Tsai-Ling Hsieh, Heng-Jun Lin, Teng-Shun Yu, Fuu-Jen Tsai, Chiu-Ying Chen and Kuang-Hsi Chang
    Citation: BMC Pharmacology and Toxicology 2024 25:24
    Content type: Research Published on:

  42. This bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into ...

    Authors: Xu Zuo, Xin Zhao, Jinjin Shi and Tiandong Zhang
    Citation: BMC Pharmacology and Toxicology 2024 25:23
    Content type: Research Published on:

  43. Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some fruits and are utilized as potent antioxidants and radioprotective agents. This...

    Authors: Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad and Dina W. Bashir
    Citation: BMC Pharmacology and Toxicology 2024 25:22
    Content type: Research Published on:

  44. This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical propert...

    Authors: Jiyu Wu, Renai Xu, Xiaowei Xu, Shiyuan Ye and Aifang Huang
    Citation: BMC Pharmacology and Toxicology 2024 25:21
    Content type: Research Published on:

  45. With the increased use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in cancer patients, adverse events (AEs) have garnered considerable interest. We conducted this pharmacovigilance study to evaluate the AEs ...

    Authors: Dehua Zhao, Xiaoqing Long and Jisheng Wang
    Citation: BMC Pharmacology and Toxicology 2024 25:20
    Content type: Research Published on:

  46. Previous studies investigating the effect of oral supplementation of paricalcitol on reactive protein levels in chronic kidney disease (CKD) patients reported inconsistent findings. In this systematic review a...

    Authors: Seyyed Mostafa Arabi, Mostafa Shahraki-Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Sara Sabeti, Mohammaed Ibrahim Mohaildeen Gubari, Basil D. Roufogalis and Amirhossein Sahebkar
    Citation: BMC Pharmacology and Toxicology 2024 25:19
    Content type: Research Published on:

  47. Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary fibrosis treatment. This stud...

    Authors: Yanjun Zeng, Rui Hu, Wei Ma, Ying Ding, Yi Zhou, Xin Peng, Lixin Feng, Qingmei Cheng and Ziqiang Luo
    Citation: BMC Pharmacology and Toxicology 2024 25:18
    Content type: Research Published on:

  48. Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored...

    Authors: Te-Yu Hung, Sheng-Nan Wu and Chin-Wei Huang
    Citation: BMC Pharmacology and Toxicology 2024 25:17
    Content type: Research Published on:

  49. Critically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate in attaining the target anti-FXa levels (0.20–0.50 IU/ml) in these g...

    Authors: Monique M.R. de Maat, Henk J. van Leeuwen, Lian Roovers, Sabine J.G.M. Ahlers, Jolanda Lambers and Marcel M.C. Hovens
    Citation: BMC Pharmacology and Toxicology 2024 25:16
    Content type: Research Published on:

  50. Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study...

    Authors: Yong-cai Wang, Xia Yang, Juan Xiao, Su-mei Wei, Ying Su, Xiu-qi Chen, Ting Huang and Qing-wen Shan
    Citation: BMC Pharmacology and Toxicology 2024 25:15
    Content type: Research Published on:
Reviewer acknowledgments
Submit manuscript

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 2.8
    5-year Journal Impact Factor: 2.8
    Source Normalized Impact per Paper (SNIP): 0.774
    SCImago Journal Rank (SJR): 0.710

    Speed 2023
    Submission to first editorial decision (median days): 25
    Submission to acceptance (median days): 178

    Usage 2023
    Downloads: 790,731
    Altmetric mentions: 400

Peer-review Terminology

  • The following summary describes the peer review process for this journal:

    Identity transparency: Single anonymized

    Reviewer interacts with: Editor

    Review information published: Review reports. Reviewer Identities reviewer opt in. Author/reviewer communication

    More information is available here

Follow

Sign up for article alerts and news from this journal

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us