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BMC Pharmacology and Toxicology

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  1. Content type: Research article

    Cholangiocarcinoma (CCA), an epithelial malignancy of the biliary tree, is one of the aggressive cancers with poor prognosis and unsatisfactory response to chemotherapy with acquired resistance. NAD(P)H-quinon...

    Authors: Pimradasiri Srijiwangsa, Saranyoo Ponnikorn and Kesara Na-Bangchang

    Citation: BMC Pharmacology and Toxicology 2018 19:32

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  2. Content type: Research article

    Patterns of opioid dispensing often exhibit substantial temporal and geographical variability, which has implications for public health policy decisions and interventions. The study examined recent trends in p...

    Authors: M Mofizul Islam, Ian S. McRae, Soumya Mazumdar, Paul Simpson, Dennis Wollersheim, Kaniz Fatema and Tony Butler

    Citation: BMC Pharmacology and Toxicology 2018 19:30

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  3. Content type: Research article

    In this analysis, we aimed to systematically compare stent thrombosis (ST) and its different subtypes following treatment with DAPT (aspirin + clopidogrel) versus TAPT (aspirin + clopidogrel + cilostazol).

    Authors: Feng Huang

    Citation: BMC Pharmacology and Toxicology 2018 19:31

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  4. Content type: Research article

    The Oslo Study of Clonidine in Elderly Patients with Delirium (LUCID) is an RCT investigating the effect of clonidine in medical patients > 65 years with delirium. To assess the dosage regimen and safety measu...

    Authors: Karen Roksund Hov, Bjørn Erik Neerland, Anders Mikal Andersen, Øystein Undseth, Vegard Bruun Wyller, Alasdair M. J. MacLullich, Eva Skovlund, Eirik Qvigstad and Torgeir Bruun Wyller

    Citation: BMC Pharmacology and Toxicology 2018 19:29

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  5. Content type: Research article

    Human Immunodeficiency Virus (HIV) is one of the main causes of morbidity and mortality; because of this it continues to be a major global public health concern. It has believed to kill more than 34 million li...

    Authors: Amsalu Bokore, Belay Korme and Getu Bayisa

    Citation: BMC Pharmacology and Toxicology 2018 19:28

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  6. Content type: Research article

    WHO pharmacovigilance indicators have been recommended as a useful tool towards improving pharmacovigilance activities. Nigeria with a myriad of medicines related issues is encouraging the growth of pharmacovi...

    Authors: Abimbola O. Opadeyi, Annie Fourrier-Réglat and Ambrose O. Isah

    Citation: BMC Pharmacology and Toxicology 2018 19:27

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  7. Content type: Research article

    Grifolic acid is a derivative of grifolin, an antitumor natural compound, and it was reported as an agonist of free fatty acid receptor GPR120. Little is known about its antitumor effects and the involvement o...

    Authors: Yufeng Zhao, Lei Zhang, Aili Yan, Di Chen, Rong Xie, Yingguang Liu, Xiangyan Liang, Yanyan Zhao, Lanlan Wei, Jun Yu, Xi Xu and Xingli Su

    Citation: BMC Pharmacology and Toxicology 2018 19:26

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  8. Content type: Research article

    Pueraria candollei var. mirifica is a medicinal plant that is promoted as a “Champion Product” by the Government of Thailand. This plant has been reported to relieve postmenopausal symptoms, prevent and reverse b...

    Authors: Tosapol Anukunwithaya, Pilaslak Poo, Natthaphon Hunsakunachai, Ratchanee Rodsiri, Suchinda Malaivijitnond and Phisit Khemawoot

    Citation: BMC Pharmacology and Toxicology 2018 19:25

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  9. Content type: Research article

    Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options agai...

    Authors: Sileshi Tadesse, Haile Alemayehu, Admasu Tenna, Getachew Tadesse, Tefaye Sisay Tessema, Workineh Shibeshi and Tadesse Eguale

    Citation: BMC Pharmacology and Toxicology 2018 19:24

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  10. Content type: Research article

    Adefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in the past few years. However, no standard guidance is available due to a ...

    Authors: Nan Chen, Jian-bo Zhang, Qiujie Zhang, Yun-peng Zhao, Li-yan Li, Li-wei Liu, Fei Yu, Xin Yu, Tao Peng and Kuan-xiao Tang

    Citation: BMC Pharmacology and Toxicology 2018 19:23

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  11. Content type: Research article

    β-blockers have several indications in critically ill patients and are commonly used. The aim of this study is to examine the relationship between the use of β-blockers in critically ill patients and mortality.

    Authors: Shmeylan A. Al Harbi, Khalid A. Al Sulaiman, Hani Tamim, Hasan M. Al-Dorzi, Musharaf Sadat and Yaseen Arabi

    Citation: BMC Pharmacology and Toxicology 2018 19:22

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  12. Content type: Research article

    Mineral trioxide aggregate (MTA) is widely used for pulp-capping procedures in permanent teeth and as a gold standard material in endodontics. The aim of the study was to investigate the effect of MTA on cell ...

    Authors: Chia-Ling Tsai, Mu-Chan Ke, Yi-Hao Chen, Hsi-Kung Kuo, Hun-Ju Yu, Chueh-Tan Chen, Ya-Chi Tseng, Pei-Chin Chuang and Pei-Chang Wu

    Citation: BMC Pharmacology and Toxicology 2018 19:21

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  14. Content type: Research article

    Rivaroxaban, a direct factor Xa inhibitor, has seldom been used in patients with coronary artery disease. In this analysis, we aimed to systematically compare the efficacy and safety of rivaroxaban in addition...

    Authors: Jun Yuan

    Citation: BMC Pharmacology and Toxicology 2018 19:19

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  15. Content type: Research article

    The use of prescription medications without the involvement of medical professionals is a growing public health concern. Therefore this study was conducted to determine the prevalence of borrowing and sharing ...

    Authors: James Henry Obol, Peter Akera, Pamela Ochola Atim, Sylvia Awor, Ronald Wanyama, Kenneth Luryama Moi, Bongomin Bodo, Patrick Olwedo Odong, Emmanuel Otto Omony, Hussein Oria, David Musoke and Felix Kaducu

    Citation: BMC Pharmacology and Toxicology 2018 19:17

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  16. Content type: Research article

    Traditional toxicological studies have relied heavily on various animal models to understand the effect of various compounds in a biological context. Considering the great cost, complexity and time involved in...

    Authors: Shan Gao, Weiyang Chen, Yingxin Zeng, Haiming Jing, Nan Zhang, Matthew Flavel, Markandeya Jois, Jing-Dong J. Han, Bo Xian and Guojun Li

    Citation: BMC Pharmacology and Toxicology 2018 19:18

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  17. Content type: Research article

    To describe frequency, preventability and seriousness of adverse drug reactions (ADRs) in children as cause of emergency department (ED) admission and to evaluate the association between specific factors and t...

    Authors: Niccolò Lombardi, Giada Crescioli, Alessandra Bettiol, Ettore Marconi, Antonio Vitiello, Roberto Bonaiuti, Anna Maria Calvani, Stefano Masi, Ersilia Lucenteforte, Alessandro Mugelli, Lisa Giovannelli and Alfredo Vannacci

    Citation: BMC Pharmacology and Toxicology 2018 19:16

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  18. Content type: Research article

    Self-medication practice (SMP) is the use of medication without the prescription of health care professionals. The major problems associated with self-medication practice have been drug resistance, drug side e...

    Authors: Aster Desalew Kassie, Berhanu Boru Bifftu and Habtamu Sewunet Mekonnen

    Citation: BMC Pharmacology and Toxicology 2018 19:15

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  19. Content type: Research article

    The efficacy of tacrolimus (TAC) is variable in the treatment of nephrotic syndrome (NS), which might be related to genetic variation among patients. Therefore, we aim to investigate the effects of CYP3 A4, CY...

    Authors: Min Li, Min Xu, Wei Liu and Xin Gao

    Citation: BMC Pharmacology and Toxicology 2018 19:14

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  20. Content type: Research article

    Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective treatment. The epithelial-mesenchymal transition (EMT) is a critical stage during the development of fibrosis. To assess...

    Authors: Sun Young Kyung, Dae Young Kim, Jin Young Yoon, Eun Suk Son, Yu Jin Kim, Jeong Woong Park and Sung Hwan Jeong

    Citation: BMC Pharmacology and Toxicology 2018 19:13

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  21. Content type: Research article

    A recent in vitro pilot investigation reported Rituximab significantly reduced natural killer (NK) cell cytotoxicity in healthy donors. Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) is a debilita...

    Authors: Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines and Sonya Marshall-Gradisnik

    Citation: BMC Pharmacology and Toxicology 2018 19:12

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  22. Content type: Research article

    This investigation aimed to evaluate the role of methylation in the regulation of microRNA (miR)-122, miR-125b and miR-106b gene expression and the expression of their target genes during isoniazid (INH)-induc...

    Authors: Yuhong Li, Qi Ren, Lingyan Zhu, Yingshu Li, Jinfeng Li, Yiyang Zhang, Guoying Zheng, Tiesheng Han, Shufeng Sun and Fumin Feng

    Citation: BMC Pharmacology and Toxicology 2018 19:11

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  23. Content type: Research article

    Accumulation of toxic free cholesterol in hepatocytes may cause hepatic inflammation and fibrosis. Volixibat inhibits bile acid reuptake via the apical sodium bile acid transporter located on the luminal surfa...

    Authors: Melissa Palmer, Lee Jennings, Debra G. Silberg, Caleb Bliss and Patrick Martin

    Citation: BMC Pharmacology and Toxicology 2018 19:10

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  24. Content type: Research article

    Based on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disord...

    Authors: Tinchou Li, Mingcheng Lee, Fuming Tsai, Yunhsiang Chen, Yiyin Lin and Maoliang Chen

    Citation: BMC Pharmacology and Toxicology 2018 19:9

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  25. Content type: Research article

    Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded o...

    Authors: Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis and Teodorico C. Ramalho

    Citation: BMC Pharmacology and Toxicology 2018 19:8

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BMC Pharmacology and Toxicology

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