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  1. High glucose conditions cause some changes in the vessels of diabetes through the signal transduction pathways. Dexamethasone and other corticosteroids have a wide range of biological effects in immunological ...

    Authors: Ali Akbar Soleimani, Asghar Mohammadi, Ghasem Ghasempour, Borhan Rahimi Abkenar, Nafiseh Shokri and Mohammad Najafi
    Citation: BMC Pharmacology and Toxicology 2022 23:63
  2. Cutaneous adverse drug reaction (CADR) is a common problem in clinical medication. This study aimed to investigate the correlation between clinical drug application and CADR occurrence as evidence for preventi...

    Authors: Lei Zheng, Hao-bin Jin, Yu-yao Guan and Jing Yang
    Citation: BMC Pharmacology and Toxicology 2022 23:62
  3. Adipose-derived mesenchymal stem cells (ADMSCs) are a promising source of material source for medical regeneration of cartilage. Growth factors, including transforming growth factor-β (TGFβ) subfamily members ...

    Authors: Masanari Kuwahara, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Takuya Sueishi, Masakazu Toya, Taisuke Uchida, Tomoaki Tsutsui, Ryota Hirose, Hidetoshi Tsushima and Yasuharu Nakashima
    Citation: BMC Pharmacology and Toxicology 2022 23:61
  4. Self-medication in students, as educated people, is one of the most important health issues. It is known that inappropriate self-medication is harmful for individuals as it has potential risks, disrupts the dr...

    Authors: Rohaneh Rahimisadegh, Nader Sharifi, Vahid Kohpeima Jahromi, Razieh Zahedi, Zahra Rostayee and Razieh Asadi
    Citation: BMC Pharmacology and Toxicology 2022 23:60
  5. Testicular torsion is a pathological condition which needs emergency surgical intervention. However, after surgical reperfusion, oxidative stress factors cause to germ cell apoptosis. The study was planned to ...

    Authors: Iraj Yazdani, Raheleh Majdani, Morteza Ghasemnejad-berenji and Ahmad Reza Dehpour
    Citation: BMC Pharmacology and Toxicology 2022 23:59
  6. The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2′E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characteriza...

    Authors: Syed Azmatullah, Arif-ullah Khan, Neelam Gul Qazi, Humaira Nadeem and Nadeem Irshad
    Citation: BMC Pharmacology and Toxicology 2022 23:58
  7. This study compared efficacy and safety of TA4415V, a trastuzumab biosimilar, with reference trastuzumab in patients with human epidermal growth factor receptor 2positive (HER2-positive) early-stage breast cance...

    Authors: Reza Safaei Nodehi, Behjat Kalantari, Jahangir Raafat, Nafiseh Ansarinejad, Vahid Moazed, Seyed Mohammad Reza Mortazavizadeh, Mehran Hosseinzadeh, Bayazid Ghaderi, Arash Jenabian, Mojtaba Qadyani, Shirin Haghighat, Abolghasem Allahyari, Mehrzad Mirzania, Mohammad Seghatoleslami, Mehrdad Payandeh, Afsaneh Alikhasi…
    Citation: BMC Pharmacology and Toxicology 2022 23:57
  8. Colorectal cancer is among the most common cancers and accounts for nearly 9% of all cancers in the world. Chrysophanol is a naturally occurring anthraquinone exerts a number of pharmacological activities s...

    Authors: Alaadin M. Naqishbandi
    Citation: BMC Pharmacology and Toxicology 2022 23:56
  9. As a progesterone receptor antagonist, mifepristone combined with misoprostol is widely used to terminate early pregnancy in clinical practice. It has also been reported that mifepristone may cause cell death ...

    Authors: Fei Tian, Hua Han, Ligang Jia, Junqin Zhang, Zhaoping Chu, Jie Li, Yuan Zhang and Ping Yan
    Citation: BMC Pharmacology and Toxicology 2022 23:55
  10. Liver fibrosis is a wound-healing response to chronic injury, featuring with excess accumulation of extracellular matrix secreted by the activated hepatic stellate cells (HSC). Disulfiram (DSF), also known as ...

    Authors: Xiao-Mei Yang, Zheng Wu, Xiaoqi Wang, Yaoqi Zhou, Lei Zhu, Dongxue Li, Hui-Zhen Nie, Ya-Hui Wang, Jun Li and Xueyun Ma
    Citation: BMC Pharmacology and Toxicology 2022 23:54
  11. The effects of age and gender were explored on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population and a plasma concentration prediction model was developed. All the data (demogra...

    Authors: Yichao Xu, Jinliang Chen, Dandan Yang, Yin Hu, Bo Jiang, Zourong Ruan and Honggang Lou
    Citation: BMC Pharmacology and Toxicology 2022 23:53
  12. Polysorbate 80 for injection (TW80) is a common excipient used for injection whose macromolecular impurities, including those that cause anaphylactoid reactions, are frequently ignored. The main aim of this st...

    Authors: Yue Li, Jinlian Duan, Heng Xia, Yongkun Li, Bin Shu and Weigang Duan
    Citation: BMC Pharmacology and Toxicology 2022 23:52
  13. Administration of antineoplastic drugs may cause azoospermia driving to subfertility. Production of animal azoospermia models is essential for evaluating new treatment methods before therapeutic interventions ...

    Authors: Halimeh Mobarak, Reza Rahbarghazi, Mohammad Nouri, Mohammad Heidarpour and Mahdi Mahdipour
    Citation: BMC Pharmacology and Toxicology 2022 23:50
  14. With diabetes incidence growing globally and metformin still being the first-line for its treatment, metformin’s toxicity and overdose have been increasing. Hence, its mortality rate is increasing. For the fir...

    Authors: Omid Mehrpour, Farhad Saeedi, Christopher Hoyte, Foster Goss and Farshad M. Shirazi
    Citation: BMC Pharmacology and Toxicology 2022 23:49
  15. Stemness of CD133+EPCAM+ hepatocellular carcinoma cells ensures cancer resistance to apoptosis,which is a challenge to current liver cancer treatments. In this study, we evaluated the tumorcidal activity of a nov...

    Authors: Danni Li, Qiying Zhang, Yuzhu Zhou, Hua Zhu, Tong Li and Fangkai Du
    Citation: BMC Pharmacology and Toxicology 2022 23:48
  16. Resveratrol (RSV) is a polyphenol compound found in grapes, veratrum and other plants. It has been reported that RSV has anti-inflammatory, anti-oxidant, anti-cancer and other pharmacological effects. However,...

    Authors: Yanli Wang, Tingting Wei, Qiang Wang, Chaonan Zhang, Keyan Li and Jinbo Deng
    Citation: BMC Pharmacology and Toxicology 2022 23:47
  17. Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exp...

    Authors: Ying-Jian Sun, Yu-Jie Liang, Lin Yang, Ding-Xin Long, Hui-Ping Wang and Yi-Jun Wu
    Citation: BMC Pharmacology and Toxicology 2022 23:46
  18. The combination of lisinopril and amlodipine has a marked additional effect on blood pressure and fewer side effects than individual monotherapy. This study was conducted to compare the pharmacokinetic paramet...

    Authors: Ting Li, Yan-ping Liu, Shu-qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-meng Gao, Ya-ping Ma and Yu Cao
    Citation: BMC Pharmacology and Toxicology 2022 23:45
  19. There were limited studies investigating treatments of septic cardiomyopathy (SCM), which is a common complication during sepsis. A septic rat model created by cecal ligation and puncture (CLP) was used to inv...

    Authors: Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du and Guoxing Wang
    Citation: BMC Pharmacology and Toxicology 2022 23:44
  20. The capsid (CA) subunit of the HIV-1 Gag polyprotein is involved in several steps of the viral cycle, from the assembly of new viral particles to the protection of the viral genome until it enters into the nuc...

    Authors: Guzmán Alvarez, Lisa van Pul, Xavier Robert, Zoraima Artía, Ad C. van Nuenen, Mathieu Long, Natalia Sierra, Williams Porcal, Neeltje A. Kootstra and Christophe Guillon
    Citation: BMC Pharmacology and Toxicology 2022 23:43
  21. Breast cancer is one of the most common types of cancer in women worldwide. Anti-apoptotic activity of cancer cells is considered the main reason for drug resistance in BC which reduces the 5-year survival rat...

    Authors: Mandana AmeliMojarad, Melika AmeliMojarad and Alireza Pourmahdian
    Citation: BMC Pharmacology and Toxicology 2022 23:42
  22. COVID-19 pandemic has claimed millions of lives and devastated the health service system, livelihood, and economy in many countries worldwide. Despite the vaccination programs in many countries, the spread of ...

    Authors: Kunlakanya Jitobaom, Chompunuch Boonarkart, Suwimon Manopwisedjaroen, Nuntaya Punyadee, Suparerk Borwornpinyo, Arunee Thitithanyanont, Panisadee Avirutnan and Prasert Auewarakul
    Citation: BMC Pharmacology and Toxicology 2022 23:41
  23. The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine.

    Authors: Heba M. Fahmy, Eman R. Mohamed, Aida A. Hussein, Yasser A. Khadrawy and Nawal A. Ahmed
    Citation: BMC Pharmacology and Toxicology 2022 23:40
  24. With an increasing number of reviews describing clinically significant drug–drug interactions (DDIs), the scope and severity of interactions involving commonly used drugs in cardiothoracic intensive care units...

    Authors: Haitao Wang, Haitao Shi, Na Wang, Yan Wang, Li Zhang, Yujie Zhao and Jiao Xie
    Citation: BMC Pharmacology and Toxicology 2022 23:39
  25. Recently, taurolidine has been intensively studied on a variety of in-vitro cancer cell-lines and first data exhibit encouraging antitumoral effects. While the clinical use of taurolidine is considered, some s...

    Authors: Agata Mikolajczyk, Veria Khosrawipour, Hien Lau, Shiri Li, Pawel Migdal, Maya Karine Labbé, Wojciech Kielan, Jakub Nicpon, Sven Stieglitz and Tanja Khosrawipour
    Citation: BMC Pharmacology and Toxicology 2022 23:38
  26. The assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There are controversial issues regarding the use of substances of different o...

    Authors: N. Bezdieniezhnykh, A. Lykhova, T. Kozak, T. Zadvornyi, T. Borikun, O. Voronina and N. Lukianova
    Citation: BMC Pharmacology and Toxicology 2022 23:37
  27. Drug-drug interactions are a major cause of morbidity worldwide and are a leading source of treatment inefficacy. They are classified based on their pharmacological action on the body as major, moderate, and m...

    Authors: Thamineni Bheema Lingaiah, Yibeltal Andarge Belay and Kokeb Dese
    Citation: BMC Pharmacology and Toxicology 2022 23:36
  28. Ethacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was earlier reported that it is also associated with bleeding upon its par...

    Authors: Srabani Kar, Kayla Vu, Madhusoodanan Mottamal and Rami A. Al-Horani
    Citation: BMC Pharmacology and Toxicology 2022 23:35
  29. Nalbuphine can relieve patients’ inflammation response after surgery compared to other opioid drugs. However, its molecular mechanism has not been clear. Activation of NF-κB signaling pathway under oxidative s...

    Authors: Dijiao Ruan, Yuanyuan Wang, Sisi Li, Chao Zhang, Wenwen Zheng and Cong Yu
    Citation: BMC Pharmacology and Toxicology 2022 23:34
  30. Tamoxifen treatment may induce dysregulation of estrogen homeostasis, leading to the occurrence of related adverse reactions. However, the potential mechanisms are still unclear. The purpose of the present stu...

    Authors: Zhixiang Hao, Jiahao Xu, Han Zhao, Wei Zhou, Zhao Liu, Shiqing He, Xiaoxing Yin, Bei Zhang, Zhongjian Wang and Xueyan Zhou
    Citation: BMC Pharmacology and Toxicology 2022 23:33
  31. Doxorubicin (DOX) is an effective antitumor agent, but its clinical usage is limited due to adverse cardiotoxic effects. Several compounds have been studied to reduce DOX cardiotoxicity to improve its therapeu...

    Authors: Maryam Shekari, Narges Khalilian Gortany, Mina Khalilzadeh, Alireza Abdollahi, Homanaz Ghafari, Ahmad Reza Dehpour and Mahmoud Ghazi-Khansari
    Citation: BMC Pharmacology and Toxicology 2022 23:32
  32. Estrogen is involved in the pathogenesis of breast and gynecological cancers. Regular use of aspirin reduces estrogen levels. The present study aimed to evaluate the effect of aspirin on estrogen levels in pos...

    Authors: Mohammad Bagher Oghazian, Nooshin Shirzad, Mahdi Ahadi, Shalaleh Eivazi Adli, Samaneh Mollazadeh and Mania Radfar
    Citation: BMC Pharmacology and Toxicology 2022 23:31
  33. Adverse drug events (ADEs) are an important public health problem with considerable clinical and economic costs. However there are limited studies of ADE incidence in adult inpatients in low-income countries, ...

    Authors: Teketel Alemu Ersulo, Mengist Awoke Yizengaw and Behailu Terefe Tesfaye
    Citation: BMC Pharmacology and Toxicology 2022 23:30
  34. Thioacetamide (TAA) is used in various fields, such as synthetic drugs, organic chemical synthesis, and materials chemistry. TAA is mainly used to establish animal liver injury models and other organ damage mo...

    Authors: Xiaoli Jin, Yang Li, Jianghua Li, Linyan Cheng, Yetao Yao, Hao Shen, Bili Wang, Jun Ren, Hang Ying and Jian Xu
    Citation: BMC Pharmacology and Toxicology 2022 23:29
  35. The use of chemical pesticides in developing countries like Bangladesh and their impacts on human health and food security is a global concern. Bangladesh is an agricultural dependent country for the growing p...

    Authors: Amir Hossan Shaikat, Shahneaz Ali Khan, Mohammed Ashif Imtiaz, Md Ridoan Pasha, Jabin Sultana, Arfanul Saif and Mohammad Rashedul Alam
    Citation: BMC Pharmacology and Toxicology 2022 23:28
  36. The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs....

    Authors: Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai and Fuhou Chang
    Citation: BMC Pharmacology and Toxicology 2022 23:26
  37. Activation of the aryl hydrocarbon receptor (AhR) can alter diurnal rhythms including those for innate lymphoid cell numbers, cytokine and hormone levels, and feeding behaviors. Because immune responses and an...

    Authors: Christine L. Foxx, Madeline R. Nagy, Aspen E. King, Dreycey Albin and Gregory K. DeKrey
    Citation: BMC Pharmacology and Toxicology 2022 23:25
  38. Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endo...

    Authors: Huanlong Liu, Zhenhua Pan, Xindi Ma, Junru Cui, Juan Gao, Qingfeng Miao, Zhongning Zhu, Xueyan Chen and Suwen Su
    Citation: BMC Pharmacology and Toxicology 2022 23:24
  39. The mixing step after medication addition to the infusion bag is frequently omitted during the preparation of drug infusions. However, the importance of mixing when preparing antibiotic infusions is still unkn...

    Authors: Ina Barzel, Janique Gabriëlle Jessurun, Soma Bahmany, Paul Hugo Marie van der Kuy, Birgit Catharina Peter Koch and Nicole Geertruida Maria Hunfeld
    Citation: BMC Pharmacology and Toxicology 2022 23:22

    The Correction to this article has been published in BMC Pharmacology and Toxicology 2022 23:27

  40. Hydroquinone (HQ) is a phenolic metabolite of benzene with a potential risk for hematological disorders and hematotoxicity in humans. In the present study, an integrative analysis of microRNA (miRNA) and mRNA ...

    Authors: Chun-Hong Yu, Shui-Qing Yang, Lei Li, Yu Xin, Fang Zhang, Xiao-Fan Liu and Zong-Chun Yi
    Citation: BMC Pharmacology and Toxicology 2022 23:20
  41. Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted...

    Authors: Hong Lee, Sang Hoon Jeong, Hyejin Lee, Cherry Kim, Yoon Jeong Nam, Ja Young Kang, Myeong Ok Song, Jin Young Choi, Jaeyoung Kim, Eun-Kee Park, Yong-Wook Baek and Ju-Han Lee
    Citation: BMC Pharmacology and Toxicology 2022 23:19
  42. Propofol and dexmedetomidine (DEX) are widely used in general anesthesia, and exert toxic and protective effects on hippocampal neurons, respectively. The study sought to investigate the molecular mechanisms o...

    Authors: Zong Chen, Yong Ding, Ying Zeng, Xue-Ping Zhang and Jian-Yan Chen
    Citation: BMC Pharmacology and Toxicology 2022 23:18
  43. Methadone is a synthetic opioid mostly used for detoxification therapy, as its use increases; the possibility for methadone-induced cardiotoxicity may rise. The aim of this study was to determine the associati...

    Authors: Hasan Shemirani, Masoumeh Sadeghi, Azadeh Davoudian Dehkordi and Farzad Gheshlaghi
    Citation: BMC Pharmacology and Toxicology 2022 23:17
  44. Arsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food Safety Authority. Lentinan, a beta-1,6;1,3-glucan extracts from Lentinus...

    Authors: Yuan Yang, Shuang Song, Yuanyuan Nie, Rong Chen and Peng Chen
    Citation: BMC Pharmacology and Toxicology 2022 23:16
  45. Arsenic metabolism enzymes can affect the toxic effects of arsenic. However, the effects of different genders on the metabolites and metabolic enzymes in liver arsenic metabolism is still unclear. This study a...

    Authors: Maihaba Muhetaer, Mei Yang, Rongxiang Xia, Yuanyan Lai and Jun Wu
    Citation: BMC Pharmacology and Toxicology 2022 23:15
  46. Digoxin is an important treatment option for reducing the ventricular rate in patients with atrial fibrillation (AF) and heart failure (HF). Digoxin has a narrow therapeutic window and large interindividual va...

    Authors: Toshinori Hirai, Hidefumi Kasai, Miyoko Naganuma, Nobuhisa Hagiwara and Tsuyoshi Shiga
    Citation: BMC Pharmacology and Toxicology 2022 23:14
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