Background
The family of KV7 potassium channels, particularly KV7.2, KV7.3, and KV7.5 controls neuronal excitability. Numerous neurotransmitters acting via G protein-coupled receptors signaling via Ca2+/calmodulin or depletion of membrane phosphatidylinositol-4,5-bisphosphate (PIP2) tightly regulate KV7 channel function. Moreover, the phosphorylation of KV7 channels has been proposed to play a crucial role. However, in vivo phosphorylation sites and their functional implications need to be determined.