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Figure 11 | BMC Pharmacology and Toxicology

Figure 11

From: 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

Figure 11

Variability of MeC and DAPI intensities in synchronized cells. (A) Mean intensities (normalized for n = ~200 cells for each) of global methylcytosine (MeC) and overall DNA (DAPI) nearly doubled between G0/G1-phase and G2-phase, with a large spread in MeC and DAPI signal distributions indicating high signal variabilities in synchronized cells. (B) In comparison MeC/DAPI codistribution patterns in the combined data of the same cells from the two phases exposed a high degree of homogeneity, which is a sign for high similarity in MeC phenotypes between cells of the two phases.

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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