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Table 3 Multivariable analysis of independent risk factors for nephrotoxicity

From: Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

Variable Odds ratio 95% confidence interval
Guideline-Recommended Vancomycin Dosing 1.52 0.75-3.08
Vancomycin duration greater than 15 days 3.36 1.79-6.34
Weight greater than 100 kilograms 2.74 1.27-5.91
Pitt Bacteremia Score of four or greater 2.73 1.29-5.79
Vancomycin trough greater than 20 mcg/ml 2.36 1.07-5.20
Age greater than 52 years 2.10 1.08-4.08
Intensive care unit residence 1.90 0.95-3.80
Concomitant nephrotoxin 1.64 0.87-3.11