Figure 2
Nicotine effect on sympathetic-stimulated whole-animals. Anesthetized rats (n=10 per group) were treated successively with isoproterenol (0.01 mg/Kg) followed by nicotine (10 μM) at 20 min intervals. Nicotine induced bradycardia in healthy rats (black circles), while inducing tachycardia in chagasic rats (gray squares). *means p < 0.05 when both groups are compared at the indicated time.