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Table 2 Mass, content of active ingredients, and dissolution time of seven generic products compared to Madopar®/Prolopa® specifications

From: Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa®

Brand name Mass (mg) Levodopa (mg) Benserazide hydrochloride (mg) Dissolution after 30 min
Tablet specifications 267.0-283.0 95.0-105.0 27.1-29.9 >75%/ >75%
Levodopa/ Benserazid beta 265 92.4* 30.9* 99% / 99%
Levodopa/ Benserazid-CT 284* 98.2 27.8 101% / 97%
dopadura B 283 94.4* 26.9* 100% / 97%
Levodopa/ Benserazide ratiopharm 284* 95.5 28.8 101% / 98%
Capsule specifications Fill mass (mg) 142.5-157.5 95.0-105.0 27.1-29.9 >80%/ >80%
Levopar 298.6* 98.3 27.5 80% / 84%
Levodopa comp. B STADA 299.0* 98.7 27.6 100% / 96%
Levobens-Teva 222.3* 99.5 28.3 89% / 86%
  1. * Values marked with an asterisk indicate deviations from Roche specifications.