Table 2 Mass, content of active ingredients, and dissolution time of seven generic products compared to Madopar®/Prolopa® specifications
Brand name | Mass (mg) | Levodopa (mg) | Benserazide hydrochloride (mg) | Dissolution after 30 min |
|---|---|---|---|---|
Tablet specifications | 267.0-283.0 | 95.0-105.0 | 27.1-29.9 | >75%/ >75% |
Levodopa/ Benserazid beta | 265 | 92.4* | 30.9* | 99% / 99% |
Levodopa/ Benserazid-CT | 284* | 98.2 | 27.8 | 101% / 97% |
dopadura B | 283 | 94.4* | 26.9* | 100% / 97% |
Levodopa/ Benserazide ratiopharm | 284* | 95.5 | 28.8 | 101% / 98% |
Capsule specifications | Fill mass (mg) 142.5-157.5 | 95.0-105.0 | 27.1-29.9 | >80%/ >80% |
Levopar | 298.6* | 98.3 | 27.5 | 80% / 84% |
Levodopa comp. B STADA | 299.0* | 98.7 | 27.6 | 100% / 96% |
Levobens-Teva | 222.3* | 99.5 | 28.3 | 89% / 86% |