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Table 1 Protein – alpha-helical peptide complexes

From: Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl–like molecules binding

Protein complex

PDB code Resolution

SwissProt code

Interacting residues of the bound alpha-helix

Chicken calmodulin in complex with smooth muscle myosin light chain kinase (smMLCK)

2O5G*

P62149

TRP5, THR8, VAL12

1.08 Å

Human calmodulin in complex with a mutant peptide of human DRP-1 kinase

1ZUZ

P62158

TRP305, PHE309, VAL312

1.91 Å

Human calmodulin in complex with CAV1.1 IQ peptide

2VAY*

P62158

THR526, ILE529, PHE533

1.94 Å

Human calmodulin in complex with CAV2.2 IQ peptide

3DVE

P62158

MET854, VAL857, MET161

2.35 Å

E Coli calmodulin in complex with RS20 peptide of smMLCK

1QTX

-

TRP5, THR8, VAL12

1.65 Å

Rat calmodulin in complex with NMDA receptor NR1C1peptide

2HQW

P62161

PHE880, THR884, LEU887

1.90 Å

Human centrin 2 in complex with the centrin binding region of XPC protein

2GGM

P41208

TRP848, LEU851, LEU855

2.35 Å

C-terminal domain of human centrin 2 in complex with a repeat sequence of human Sfi 1

2K2I

P41208

LEU651, LEU655, TRP658

NMR

Scherffelia dubia centrin in complex with smMLCK peptide

3KF9

Q06827

TRP4, PHE8, VAL11

2.60 Å

Human BCL-XL in complex with BAK peptide

1BXL*

Q07817

VAL574, LEU578, ILE581

NMR

Human E3 ubiquitin-protein ligase MDM2 in complex with p53 tumor transactivation domain (fragment 17-125)

1YCR*

Q00987

PHE19, TRP23, LEU26

2.60 Å

Rabbit cardiac troponin C in complex with a fragment (residues 1-47) of cardiac troponin I

1A2X

P02586

LEU17, MET21, ILE24

 

2.30 Å

  
  1. *known to be disrupted by terphenyl or its derivatives.