Figure 1

Phenotypic behavior of allosters. Panel A. Some concentration-response curves with an alloster present demonstrating enhancement and allo-inhibition of both a mixed and a competitive type antagonism and with ceiling effects for all three. The red curve represents an orthoster concentration-response in the absence of an alloster. Panel B. Concentration-response relations with an alloster present, displaying allo-agonism as a lifted initial activity with ceiling and allo-synergy as a lifted maximal response. Both allo-agonism and synergy curves are lifted compared to a concentration-response curve with no alloster present as in the green curve. Definitions of phenotypic alloster terms are listed in Table 1.