Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes

Table 1 Parameter estimates of the final anakinra population pharmacokinetic model in 87 pediatric patients

Key: CL/F, apparent elimination clearance; V/F, apparent volume of distribution; Ka, absorption rate constant; F, unknown bioavailability; TV(), typical value for the mean covariate value; β, covariate effect parameter; η, between-subject variability; γ, between occasion variability; ϵ, constant residual variability; BW, bodyweight (CL/F and V/F estimates are normalized to a 70 kg BW).