|
Parameter
|
Estimate
|
Relative standard error (%)
|
|---|
|
CL/F (L h-1 70 kg-1)
|
6.24
|
8
|
|
βCL, TV(CL)∙(BW/70)βCL
|
0.47
|
14
|
|
V/F (L)
|
65.2
|
12
|
|
βV, TV(V)∙(BW/70)βV
|
0.76
|
16
|
|
Ka (h-1)
|
0.38
|
19
|
|
ηCL/F
|
0.28
|
15
|
|
γV/F
|
0.47
|
17
|
|
ϵ, mg/L
|
0.072
|
10
|
- Key: CL/F, apparent elimination clearance; V/F, apparent volume of distribution; Ka, absorption rate constant; F, unknown bioavailability; TV(), typical value for the mean covariate value; β, covariate effect parameter; η, between-subject variability; γ, between occasion variability; ϵ, constant residual variability; BW, bodyweight (CL/F and V/F estimates are normalized to a 70 kg BW).
