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Table 6 Causes of death in diabetic foot ulcer patients treated with intralesional hrEGF

From: Active post-marketing surveillance of the intralesional administration of human recombinant epidermal growth factor in diabetic foot ulcers

Cause Number Percent of all deaths Rate (per 100 person-years)
Cardiovascular disorders 145 41.2% 6.38%
Acute myocardial infarct 37 10.5% 1.63%
Stroke and its sequels 33 9.4% 1.45%
Ischemic cardiopathy 29 8.2% 1.28%
Cardiac failure 18 5.1% 0.79%
Hypertensive cardiac disease 9 2.6% 0.40%
Other: peripheral angiopathy (5); acute pulmonary edema (4); cardiac arrhythmias (4); cardiac arrest and cardiogenic shock (3); generalized atherosclerosis; non specified (2); abdominal aorta aneurism rupture (1) 19 5.4% 0.84%
Other complications of diabetes 60 17.0% 2.64%
Diabetic coma 6 1.7% 0.26%
Diabetes mellitus with renal complications 30 8.5% 1.32%
Diabetes mellitus with other complications 13 3.7% 0.57%
Diabetic foot 11 3.1% 0.48%
Respiratory disorders 53 15.1% 2.33%
Pneumonia and bronchopneumonia 49 13.9% 2.16%
Acute respiratory insufficiency 4 1.1% 0.18%
Neoplasia: breast (8); prostate (3); colon (4); bladder (2); lung (3); peritoneum (2); pancreas (1); kidney (1); pharynx (1); spinal column (1); mouth (1); tumor of unknown behavior, encephalus, suptratentorial (1) 28 8.0% 1.23%
Peripheral venous thrombosis and thromboembolism 12 3.4% 0.53%
Amputations and other surgical complications 12 3.4% 0.53%
Other causes: sepsis (8); upper digestive bleeding (4); gastroenteritis (2); liver cirrhosis (2); rheumatoid arthritis (1); viral encephalitis (not specified) (1); multiorgan failure (1); alcoholic hepatitis (1); prostate hyperplasia (1); accidents and traumatisms (2); sudden death (1) 24 6.8% 1.06%
Unknown 18 5.1%  
Total 352   15.50%
  1. (From the national death certificate database).