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Table 6 Causes of death in diabetic foot ulcer patients treated with intralesional hrEGF

From: Active post-marketing surveillance of the intralesional administration of human recombinant epidermal growth factor in diabetic foot ulcers

Cause

Number

Percent of all deaths

Rate (per 100 person-years)

Cardiovascular disorders

145

41.2%

6.38%

Acute myocardial infarct

37

10.5%

1.63%

Stroke and its sequels

33

9.4%

1.45%

Ischemic cardiopathy

29

8.2%

1.28%

Cardiac failure

18

5.1%

0.79%

Hypertensive cardiac disease

9

2.6%

0.40%

Other: peripheral angiopathy (5); acute pulmonary edema (4); cardiac arrhythmias (4); cardiac arrest and cardiogenic shock (3); generalized atherosclerosis; non specified (2); abdominal aorta aneurism rupture (1)

19

5.4%

0.84%

Other complications of diabetes

60

17.0%

2.64%

Diabetic coma

6

1.7%

0.26%

Diabetes mellitus with renal complications

30

8.5%

1.32%

Diabetes mellitus with other complications

13

3.7%

0.57%

Diabetic foot

11

3.1%

0.48%

Respiratory disorders

53

15.1%

2.33%

Pneumonia and bronchopneumonia

49

13.9%

2.16%

Acute respiratory insufficiency

4

1.1%

0.18%

Neoplasia: breast (8); prostate (3); colon (4); bladder (2); lung (3); peritoneum (2); pancreas (1); kidney (1); pharynx (1); spinal column (1); mouth (1); tumor of unknown behavior, encephalus, suptratentorial (1)

28

8.0%

1.23%

Peripheral venous thrombosis and thromboembolism

12

3.4%

0.53%

Amputations and other surgical complications

12

3.4%

0.53%

Other causes: sepsis (8); upper digestive bleeding (4); gastroenteritis (2); liver cirrhosis (2); rheumatoid arthritis (1); viral encephalitis (not specified) (1); multiorgan failure (1); alcoholic hepatitis (1); prostate hyperplasia (1); accidents and traumatisms (2); sudden death (1)

24

6.8%

1.06%

Unknown

18

5.1%

 

Total

352

 

15.50%

  1. (From the national death certificate database).