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Table 2 KLF4 mRNA fold changes in H9C2 from the gene microarrays and subsequent confirmation using qRT-PCR

From: Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

  qRT-PCR Affymetrix
Amiodarone 2.2 1.62
Amitryptiline 2.8 2.3
Cyclosporine 2.1 1.84
Dexamethasone 1.3 2.14
Dobutamine 1.7 1.93
Doxorubicin −9.7* −4.92*
Loratadine 2.4 2.1
Mitoxantrone 1.4 2.06
  1. *The decreased levels in Doxorubicin might be a reflection of severe cytotoxicity. However, KLF4 measurement at a lower dose (IC20 instead of IC50) resulted in 2.52 fold increase.