BMC Pharmacology and Toxicology

Table 3 Predicted TGFB signaling in vivo and in cell lines

From: Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

	Predicted TGFB signaling
	In vivo	H9C2	RCM
Amiodarone	↑	↓	↓
Amitryptiline	↑	↓	↓
Cyclosporine	↑	↔	↓
Dexamethasone	↑	↑	↔
Dobutamine	↑	↓	↓
Doxorubicin	↑	↑	↓
Loratadine	↑	↓	↓
Mitoxantrone	↑	↓	↓

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ISSN: 2050-6511

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