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Table 3 Pharmacokinetic parameters of CR8 in different organs following single oral administration of 100 mg/kg

From: Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

  Plasma Liver Adipose tissue Kidney Lung Spleen Bone marrow Brain
AUC (μg.hr/g) 96 197 181 145 77 40 34 14
Beta-HL (hr) 3.10 2.43 2.40 2.62 2.58 2.60 1.98 2.12
Cmax (μg/ml) 34.3 52.4 48.7 36.0 19.3 27.7 10.6 4.1
CL/F 21.0 10.2 11.1 13.8 26.2 20.0 29.5 146.0
V2/F 21.0 35.8 38.2 52.2 96.7 74.5 84.5 447.5