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Table 1 Pharmacokinetic parameters of riociguat in plasma following a single oral dose of riociguat 1 mg

From: Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

Parameter Child–Pugh A (n = 16) Child–Pugh B (n = 16) Control A (n = 16) Control B (n = 16)
AUC, μg·h/L 371.0 (74) 458.9 (62) 349.9 (67) 300.9 (92)
Cmax, μg/L 42.67 (37) 43.27 (39) 42.67 (23) 38.68 (30)
AUCnorm, kg·h/L 30.9 (75) 36.6 (65) 29.1 (67) 23.9 (94)
Cmax,norm, kg/L 3.56 (33) 3.45 (26) 3.55 (20) 3.07 (23)
t½, h 9.19 (53) 13.7 (50) 9.02 (63) 7.54 (86)
  1. Values are geometric means (percentage coefficient of variation). AUC, area under the plasma concentration–time curve from time 0 to infinity; AUCnorm, AUC divided by dose per kilogram of body weight for total riociguat; Cmax, maximum concentration in plasma; Cmax,norm, Cmax divided by dose per kilogram of body weight for total riociguat; t½, terminal elimination half-life for total riociguat.