|
Parameter
|
Young female (n = 9)
|
Elderly female (n = 9)
|
Young male (n = 9)
|
Elderly male (n = 9)
|
|---|
|
Riociguat
| | | | |
|
AUC, μg·h/L
|
803 (55)
|
1145 (36)
|
750 (58)
|
1036 (48)
|
|
Cmax, μg/L
|
113 (22)
|
125 (35)
|
80.4 (25)
|
96.7 (32)
|
|
AUCnorm, g·h/L
|
24.8 (57)
|
32.6 (45)
|
26.5 (55)
|
32.8 (50)
|
|
Cmax,norm, g/L
|
3.48 (20)
|
3.56 (36)
|
2.84 (23)
|
3.06 (22)
|
|
t½, h
|
8.97 (51)
|
11.8 (31)
|
8.10 (39)
|
12.2 (62)
|
|
CLR, L/ha
|
0.320 (28)
|
0.223 (33)
|
0.389 (37)
|
0.287 (28)
|
|
M1
| | | | |
|
AUC, μg·h/L
|
640 (26)
|
651 (38)
|
476 (20)
|
687 (44)
|
|
Cmax, μg/L
|
28.1 (53)
|
22.4 (52)
|
14.9 (44)
|
18.8 (71)
|
|
AUCnorm, g·h/L
|
20.5 (26)
|
19.2 (30)
|
17.4 (28)
|
22.5 (35)
|
|
Cmax,norm, g/L
|
0.899 (51)
|
0.661 (42)
|
0.544 (51)
|
0.615 (65)
|
|
t½, h
|
16.0 (34)
|
16.7 (21)
|
14.9 (28)
|
21.3 (33)
|
|
CLR, L/ha
|
0.824 (32)
|
0.487 (36)
|
0.718 (39)
|
0.573 (44)
|
- aArithmetic mean (percentage coefficient of variation). All other parameters are expressed as geometric means (percentage coefficient of variation).
- AUC, area under the plasma concentration–time curve from time 0 to infinity; AUCnorm, AUC divided by dose per kilogram of body weight; Cmax, maximum concentration in plasma; Cmax,norm, Cmax divided by dose per kilogram of body weight; t½, terminal elimination half-life; CLR, renal clearance.
