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Table 2 Comparison of selected riociguat and M1 pharmacokinetic parameters between different participant groups (ratios and 90% confidence limits)

From: Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat

Parameter Elderly vs young (n = 18 per group) Female vs male (n = 18 per group)
Riociguat   
AUC 1.40 (1.06–1.86) 1.09 (0.82–1.44)
Cmax 1.16 (0.98–1.36) 1.35 (1.14–1.59)*
AUCnorm 1.28 (0.95–1.71) 0.97 (0.72–1.30)
Cmax,norm 1.05 (0.91–1.22) 1.20 (1.03–1.38)*
t½ 1.41 (1.08–1.84)* 1.04 (0.79–1.35)
M1   
AUC 1.21 (1.00–1.46) 1.13 (0.94–1.36)
Cmax 1.00 (0.73–1.38) 1.50 (1.09–2.05)*
AUCnorm 1.10 (0.93–1.30) 1.00 (0.85–1.19)
Cmax,norm 0.91 (0.68–1.23) 1.33 (0.99–1.79)
t½ 1.22 (1.04–1.44)* 0.92 (0.78–1.08)
  1. *p < 0.05 for ratio = 1.
  2. AUC, area under the plasma concentration–time curve from time 0 to infinity; AUCnorm, AUC divided by dose per kilogram of body weight; Cmax, maximum concentration in plasma; Cmax,norm, Cmax divided by dose per kilogram of body weight; t½, terminal elimination half-life.