From: Effects of omeprazole and AlOH/MgOH on riociguat absorption
Riociguat/omeprazole study | Riociguat/AlOH/MgOH study | |||||||
---|---|---|---|---|---|---|---|---|
Parametera | Riociguat 2.5 mg (n=12) | Riociguat 2.5 mg + omeprazole (n=12) | Riociguat 2.5 mg (n=12) | Riociguat 2.5 mg + AlOH/MgOH (n=12) | ||||
GM | %CV | GM | %CV | GM | %CV | GM | %CV | |
AUC (µg⋅h/L) | 587.9 | 71.9 | 432.8 | 79.8 | 465.9 | 68.2 | 309.6 | 87.2 |
Cmax (µg/L) | 73.8 | 26.6 | 48.1 | 33.8 | 80.8 | 38.4 | 35.5 | 57.1 |
tmax (h) | 3.0 | – | 3.0 | – | 1.0 | – | 2.5 | – |
t1/2 (h) | 7.9 | 46.4 | 9.0 | 25.4 | 5.9 | 44.4 | 8.6 | 53.8 |
CL/f | 4.3 | 71.9 | 5.8 | 79.8 | 5.4 | 68.2 | 8.1 | 87.2 |