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Table 1 Riociguat pharmacokinetic parameters (geometric means and coefficients of variation)

From: Effects of omeprazole and AlOH/MgOH on riociguat absorption

  Riociguat/omeprazole study Riociguat/AlOH/MgOH study
Parametera Riociguat 2.5 mg (n=12) Riociguat 2.5 mg + omeprazole (n=12) Riociguat 2.5 mg (n=12) Riociguat 2.5 mg + AlOH/MgOH (n=12)
  GM %CV GM %CV GM %CV GM %CV
AUC (µgh/L) 587.9 71.9 432.8 79.8 465.9 68.2 309.6 87.2
Cmax (µg/L) 73.8 26.6 48.1 33.8 80.8 38.4 35.5 57.1
tmax (h) 3.0 3.0 1.0 2.5
t1/2 (h) 7.9 46.4 9.0 25.4 5.9 44.4 8.6 53.8
CL/f 4.3 71.9 5.8 79.8 5.4 68.2 8.1 87.2
  1. AUC, area under plasma concentration–time curve; CL/f, total riociguat clearance from plasma; Cmax, maximum riociguat plasma concentration; CV, coefficient of variation; GM, geometric mean; t1/2, elimination half-life; tmax, time to reach Cmax.
  2. aData are mean except tmax, which is median.