Figure 1From: The development of response surface pathway design to reduce animal numbers in toxicity studies The pathway obtained in the in vivo Yessotoxin study using the basic 4-level RSP design. The basic 4-level RSP design in in vivo Yessotoxin study used 9 mice on each design level with the binomial outcome. The pathway obtained is indicated by dashed line. The doses are given in μg/kg BW and the numbers given in brackets are the ratios of dead mice.Back to article page