Effect of CNX-011-67 in normal wistar rats and rat islets- OGTT glucose, insulin and GSIS. Effects of CNX-011-67 on blood glucose and insulin levels in normal Wistar rats with (A) and without glucose load (B). The rats were dosed with vehicle or CNX-011-67 by oral gavage at −45 min, blood samples obtained at the time intervals indicated in the graphs for glucose and insulin estimation. Effects of CNX-011-67 on total blood glucose (C) & insulin (D) AUC during the OGTT in Wistar rats. Effects of CNX-011-67 on total insulin (E) & blood glucose (F) AUC during the OGTT without glucose load in Wistar rats. The percent inhibition of glucose levels was calculated based on the glucose AUC during the 0-120 min OGTT for each group after subtracting the values from those of the normal (no drug and no glucose) control group. Data in all panels are mean ± SEM (n = 8/group). Statistical comparison between control and treatment group was conducted by one-way ANOVA followed by Dunnett’s post test correction. (*P < 0.05 and ** P < 0.01).