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Table 3 Comparison of early and late clinical and pharmacokinetic parameters in the 7 patients who completed two pharmacokinetic assessments

From: Assessment of pharmacokinetic changes of meropenem during therapy in septic critically ill patients

 

Early

Late

P-value*

Cr Cl (mL/min)

66.7 [31.7]

106.7 [46.7]

0.128

SOFA

6 [3.5]

3 [1]

0.042

V ss (L)

18.5 (13.0-26.4)

17.3 (7.3-41.0)

0.866

V ss /Weight (l/kg)

0.25 (0.17-0.36)

0.23 (0.1-0.53)

0.866

V ss2 / V ss (%)

61.3 (42.5-88.5)

51.7 (36.6-73.1)

0.176

Cl (mL/min)

120 (75–188.3)

135 (73.3-228.3)

0.398

Trough (mg/L)

2.6 (1.1-6.4)

1.5 (0.4-5.9)

0.172

  1. Cr Cl – Creatine Clearance; SOFA- Sequential organ failure assessment score; V ss – Volume of distribuition at steady state; V ss2 – Volume of distribution at steady state of the peripheral compartment; Cl – Meropenem Clearance; Early – Parameters measured within the first 36 hrs of meropenem therapy; Late – Parameters measured after the 5th day of meropenem therapy. *Wilcoxon signed ranks test. Data presented as geometric mean (95% confidence interval of the mean) or median [IQR].
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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