Skip to main content

Table 3 Comparison of early and late clinical and pharmacokinetic parameters in the 7 patients who completed two pharmacokinetic assessments

From: Assessment of pharmacokinetic changes of meropenem during therapy in septic critically ill patients

  Early Late P-value*
Cr Cl (mL/min) 66.7 [31.7] 106.7 [46.7] 0.128
SOFA 6 [3.5] 3 [1] 0.042
V ss (L) 18.5 (13.0-26.4) 17.3 (7.3-41.0) 0.866
V ss /Weight (l/kg) 0.25 (0.17-0.36) 0.23 (0.1-0.53) 0.866
V ss2 / V ss (%) 61.3 (42.5-88.5) 51.7 (36.6-73.1) 0.176
Cl (mL/min) 120 (75–188.3) 135 (73.3-228.3) 0.398
Trough (mg/L) 2.6 (1.1-6.4) 1.5 (0.4-5.9) 0.172
  1. Cr Cl – Creatine Clearance; SOFA- Sequential organ failure assessment score; V ss – Volume of distribuition at steady state; V ss2 – Volume of distribution at steady state of the peripheral compartment; Cl – Meropenem Clearance; Early – Parameters measured within the first 36 hrs of meropenem therapy; Late – Parameters measured after the 5th day of meropenem therapy. *Wilcoxon signed ranks test. Data presented as geometric mean (95% confidence interval of the mean) or median [IQR].