Table 1 Serum analysis
Acute, 24 h, single dose | Chronic, 30 day, daily dose | ||||||
|---|---|---|---|---|---|---|---|
Control | 10 mg/kg | 100 mg/kg | Control | 3 mg/kg | 10 mg/kg | ||
N = 3 | N = 8 | N = 8 | N = 9 | N = 10 | N = 9 | ||
Normal range | Mean | Mean | Mean | Mean | Mean | Mean | |
Alanine aminotransferase U/L | 22–133 | 30.7 | 36.1 | 1282.9*** | 52.1 | 43.1 | 38.4 |
Aspartate aminotransferase U/L | 46–221 | 63.3 | 89.5 | 565.3** | 367.0 | 150.9 | 236.2 |
Albumin g/dL | 2.6–5.4 | 2.2 | 2.3 | 1.9 | 2.8 | 2.8 | 2.7 |
Alkaline phosphatase U/L | 16–200 | 107.7 | 126.1 | 101.5 | 98.1 | 104.4 | 106.1 |
Creatinine mg/dL | 0.1–1.8 | 0.2 | 0.2 | 0.4 | 0.2 | 0.3 | 0.2 |
Total bilirubin mg/dL | 0.3–0.7 | 0.2 | 0.2 | 0.3 | 0.3 | 0.2 | 0.2 |
Lactate dehydrogenase U/L | 109–647 | 235.0 | 325.2 | 2439.8*** | 486.6 | 507.0 | 483.0 |
Blood urea nitrogen mg/dL | 2–71 | 22.3 | 19.8 | 22.0 | 21.8 | 22.3 | 24.1 |
Cholesterol mg/dL | 34–173 | 93.0 | 91.5 | 20.8** | 92.3 | 80.9 | 56.8** |
Total protein g/dL | 4.6–7.3 | 4.0 | 3.7 | 3.6 | 4.8 | 4.7 | 4.6 |
Glucose mg/dL | 60–133 | 286.0 | 297.8 | 104.3*** | 250.6 | 256.7 | 233.9 |