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Table 1 Serum analysis

From: Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

   Acute, 24 h, single dose Chronic, 30 day, daily dose
   Control 10 mg/kg 100 mg/kg Control 3 mg/kg 10 mg/kg
   N = 3 N = 8 N = 8 N = 9 N = 10 N = 9
  Normal range Mean Mean Mean Mean Mean Mean
Alanine aminotransferase U/L 22–133 30.7 36.1 1282.9*** 52.1 43.1 38.4
Aspartate aminotransferase U/L 46–221 63.3 89.5 565.3** 367.0 150.9 236.2
Albumin g/dL 2.6–5.4 2.2 2.3 1.9 2.8 2.8 2.7
Alkaline phosphatase U/L 16–200 107.7 126.1 101.5 98.1 104.4 106.1
Creatinine mg/dL 0.1–1.8 0.2 0.2 0.4 0.2 0.3 0.2
Total bilirubin mg/dL 0.3–0.7 0.2 0.2 0.3 0.3 0.2 0.2
Lactate dehydrogenase U/L 109–647 235.0 325.2 2439.8*** 486.6 507.0 483.0
Blood urea nitrogen mg/dL 2–71 22.3 19.8 22.0 21.8 22.3 24.1
Cholesterol mg/dL 34–173 93.0 91.5 20.8** 92.3 80.9 56.8**
Total protein g/dL 4.6–7.3 4.0 3.7 3.6 4.8 4.7 4.6
Glucose mg/dL 60–133 286.0 297.8 104.3*** 250.6 256.7 233.9
  1. **p < 0.01. ***p < 0.001.
  2. Values significantly different from the control group are highlighted in boldface.