Increased uridine salvage protects liver against tamoxifen-induced lipid accumulation. (A) CARS images of liver tissues of wildtype C57BL/6J and transgenic UPase1
−/−and UPase1-TG mice as a function of tamoxifen treatment. (B) Liver lipid level determined with CARS image analysis. (C) Liver triacylglyceride (TAG) levels determined with biochemical assays. Error bars are standard deviation values across 9 mice analyzed per animal group. Single asterisk (black) indicates p-value < 0.05 versus untreated control mice. Double asterisks (gray) indicate p-value < 0.05 versus C57BL/6J mice treated with tamoxifen.