Table 1 Physiological results from pressure regulated perfusion
From: Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat
DIADOX | DIA5HDDOX | 5HDDOX | DIASAL | 5HDSAL | SALSAL | SALDOX | |
|---|---|---|---|---|---|---|---|
LVDP (mmHg) | 136.6 ± 2.9* | 122.9 ± 4.4 | 117.5 ± 5.2 | 146.4 ± 6.8* | 144.6 ± 5.1* | 152.7 ± 11.0* | 120.4 ± 3.6 |
LVEDP (mmHg) | 9.3 ± 1.5* | 16.1 ± 1.8 | 14.9 ± 2.7 | 8.2 ± 1.5* | 8.1 ± 1.6* | 8.3. ± 1.6* | 15.4 ± 2.2 |
AoP (mmHg) | 73.0 ± 0 | 73.0 ± 0 | 73.0 ± 0 | 73.0 ± 0 | 73.0 ± 0 | 73.0 ± 0 | 73.0 ± 0 |
Heart rate (beats per minute) | 300 ± 0 | 300 ± 0 | 300 ± 0 | 300 ± 0 | 300 ± 0 | 300 ± 0 | 300 ± 0 |
dp/dtmax (mmHg/s) | 3525.5 ± 949.9 | 3295.3 ± 895.9 | 3283.4 ± 621.9 | 3647.4 ± 563.7 | 3522.5 ± 120.1 | 4499.1 ± 887.2 | 3026.6 ± 150.0 |
dp/dtmin (mmHg/s) | −2176.5 ± 1147.9 | −2012.3 ± 282.3 | −1952.7 ± 373.9 | −2921.9 ± 200.3 | −3050.9 ± 277.6 | −3060.1 ± 311.3 | −2173.0 ± 195.1 |
Coronary flow (ml/min) | 11.3 ± 1.8* | 9.5 ± 0.7 | 8.8 ± 1.2 | 11.8 ± 1.2* | 12.0 ± 1.3* | 12.6 ± 0.4* | 8.9 ± 1.7 |