Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Table 2 Distribution of major reasons and documented ADRs responsible for treatment change (based on chart review), ART clinic, Gondar University Hospital, June 2012

Variables	n (%)^*
Reasons for treatment change (N = 78)
Due to ADRs	62 (79.0) ^**
Due to treatment failure	10 (13.0)
Due to TB co-morbidity	4 (5.0)
Due to pregnancy	2 (3.0)
Documented ADRs responsible for treatment change (N = 62)
CNS symptoms	17 (27.4)
Anemia	10 (16.1)
Peripheral neuropathy	9(14.5)
Skin rash	8 (12.9)
Lipodystrophy	7(11.3)
Weight loss	4(6.5)
Stomach ache	3 (4.8)
Hepatotoxicity	3 (4.8)
Dental illness	1 (1.6)

^*Percent frequency out of the total number of patients (reasons for treatment change, N = 78; ADRs responsible for treatment change, N = 62). The most frequent reasons are highlighted in bold type.
^**95% CI, 0.68-0.88; p =0.00.