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Table 2 Distribution of major reasons and documented ADRs responsible for treatment change (based on chart review), ART clinic, Gondar University Hospital, June 2012

From: Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Variables

n (%)*

Reasons for treatment change (N = 78)

 

  Due to ADRs

62 (79.0) **

  Due to treatment failure

10 (13.0)

  Due to TB co-morbidity

4 (5.0)

  Due to pregnancy

2 (3.0)

Documented ADRs responsible for treatment change (N = 62)

  CNS symptoms

17 (27.4)

  Anemia

10 (16.1)

  Peripheral neuropathy

9(14.5)

  Skin rash

8 (12.9)

  Lipodystrophy

7(11.3)

  Weight loss

4(6.5)

  Stomach ache

3 (4.8)

  Hepatotoxicity

3 (4.8)

  Dental illness

1 (1.6)

  1. *Percent frequency out of the total number of patients (reasons for treatment change, N = 78; ADRs responsible for treatment change, N = 62). The most frequent reasons are highlighted in bold type.
  2. **95% CI, 0.68-0.88; p =0.00.