Evaluation of lung recovery after static administration of three different perfluorocarbons in pigs

Table 1 Hemodynamic parameters and temperatures throughout protocol

	Baseline	Time after perfluorocarbon administration (h)
		1	12	48	96
Number of animals
Control	4	4	4	4	4
PFD	4	4	4	3*	3*
PFOC	4	4	4	4	4
PFOB	4	4	4	4	4
Body weight (kg)
Control	23.9 ± 0.5	-	-	-	23.9 ± 1.1
PFD	25.1 ± 2.0	-	-	-	22.8 ± 1.0
PFOC	24.5 ± 0.8	-	-	-	24.0 ± 0.8
PFOB	22.2 ± 1.2	-	-	-	22.4 ± 0.6
Heart rate (beats/min)
Control	115 ± 7	106 ± 4	87 ± 3	103 ± 3	112 ± 9
PFD	121 ± 7	114 ± 7	99 ± 5	116 ± 9	115 ± 7
PFOC	121 ± 5	120 ± 5	96 ± 4	110 ± 9	114 ± 7
PFOB	121 ± 18	119 ± 17	96 ± 9	115 ± 12	113 ± 10
Mean arterial pressure (mmHg)
Control	82 ± 5	81 ± 5	79 ± 7	91 ± 3	77 ± 5
PFD	87 ± 7	85 ± 5	82 ± 5	91 ± 10	101 ± 12
PFOC	81 ± 6	77 ± 3	72 ± 2	97 ± 12	97 ± 3
PFOB	77 ± 4	75 ± 2	75 ± 5	99 ± 8	94 ± 7
Rectal temperature (°C)
Control	38.2 ± 0.2	38.2 ± 0.1	38.2 ± 0.1	38.6 ± 0.4	38.2 ± 0.3
PFD	37.8 ± 0.1	37.7 ± 0.2	38.2 ± 0.2	38.3 ± 0.3	37.9 ± 0.2
PFOC	37.8 ± 0.1	38.0 ± 0.2	38.2 ± 0.1	38.6 ± 0.1	38.5 ± 0.3
PFOB	38.1 ± 0.1	38.1 ± 0.1	38.2 ± 0.1	38.6 ± 0.1	38.5 ± 0.2
Esophageal temperature (°C)
Control	37.8 ± 0.1	38.18 ± 0.1	38.1 ± 0.1	-	-
PFD	37.7 ± 0.2	37.65 ± 0.3	38.1 ± 0.3	-	-
PFOC	37.7 ± 0.1	37.8 ± 0.2	38.1 ± 0.2	-	-
PFOB	38.1 ± 0.1	38.08 ± 0.1	38.4 ± 0.1	-	-

PFD, perfluorodecalin; PFOC, perfluoro-N-octane; PFOB, perfluorooctylbromide; *, One animal was euthanized for respiratory distress at t = 24 h in the PFD group.

ISSN: 2050-6511