Magnesium supplementation and high volume hydration reduce the renal toxicity caused by cisplatin-based chemotherapy in patients with lung cancer: a toxicity study

Table 1 An example of the chemotherapy hydration regimen for each group

		High-volume hydration Mg-		High-volume hydration Mg+		Low-volume hydration Mg+
			ml		ml		ml
Day 1		N.S.	50	N.S.	50	N.S.	50
	Antiemetics					N.S.	100
		Granisetoron 3 mg	100	Granisetoron 3 mg	100	Fosaprepitant meglumine 150 mg
		Dexamethasone 6.6 mg	2	Dexamethasone 6.6 mg	2	N.S.	50
						Palonosetoron 0.75 mg	5
						Dexamethasone 9.9 mg	2
	Other cytotoxic agent	N.S. with other cytotoxic agent	500	N.S. with other cytotoxic agent	500	N.S. with other cytotoxic agent	100
	Pre-hydration	N.S.	500	N.S.	500	1/4 saline solution	500
		1/4 saline solution	500	1/4 saline solution	500	MgSO₄ 8 mEq
				MgSO₄ 8 mEq
	Diuresis			20% Mannitol	300	20% Mannitol	300
	Cisplatin	N.S. with cisplatin	300	N.S. with cisplatin	300	N.S. with cisplatin	100
	Post-hydration	N.S.	500	N.S.	500	N.S.	500
	Diuresis	20% Mannitol	300
	Post-hydration	1/4 saline solution	500	1/4 saline solution	500	1/4 saline solution	500
	Diuresis	20% Mannitol	300	20% Mannitol	300
		Frosemide 20 mg	2	Frosemide 20 mg	2
	Oral hydration		0		0		2,000
Day 2,3		N.S.	50	N.S.	50
	Antiemetics	Granisetoron 3 mg	100	Granisetoron 3 mg	100
		Dexamethasone 6.6 mg	2	Dexamethasone 6.6 mg	2
	Hydration	1/4 saline solution	500	1/4 saline solution	500
	Diuresis	20% Mannitol	300	20% Mannitol	300
	Oral hydration		0		0		1,000
	Total infusion	Day 1	3,550	Day 1	3,550	Day 1	2,200
		Day 2,3	950	Day 2,3	950	Day 2,3	0

ISSN: 2050-6511