Skip to main content

Table 5 Proposed optimal doses given CYP2B6 genotypes, weight and gender

From: CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe

Variable   Females Males
   <58 kg >58 kg <58 kg >58 kg
CYP2B6*18 CYP2B6*6 1 -4 μg/ml 1 -4 μg/ml 1 -4 μg/ml 1 -4 μg/ml
TT GG 400 400 400 400
TT GT 200 200 200 200
TT TT 200 200 200 200
TC GG 400 400 400 400
TC GT 400 200 200 200
TC TT 200 200 200 200
CC GG 400 600 600 600
CC GT 200 300 300 300
CC TT 200 200 200 200