Fig. 5
From: A novel nasal powder formulation of glucagon: toxicology studies in animal models
Mean (+ SE) uncorrected glucagon serum concentration profiles in dogs following multiple intra-nasal administrations—Day 28. Glucagon concentrations on Day 28 (linear scale). All samples collected from placebo-control powder and saline-control animals displayed glucagon levels < LLOQ with the exception of three samples, one from the saline-control group at pre-dose (animal 2503, 211 pg/mL) and three from the placebo-control powder group at pre-dose and 20 min post-dosing (animal 1501, 229 pg/mL, animal 1502, 355 pg/mL, and animal 1503, 201 pg/mL, respectively). On Day 28, following daily dosing for 28 consecutive days, pre-dose samples collected from low- and high-dose GNP groups generally displayed measurable glucagon levels