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Table 2 Summary toxicokinetic parameters of glucagon in rats (gender combined)

From: A novel nasal powder formulation of glucagon: toxicology studies in animal models

Day Group Dose level of glucagon (mg/day) Mean (± SE)
AUC0–t (pg min/mL) AUC0–90 (pg min/mL) Cmax (pg/mL) tmax (min) RA
1 Low dose 0.1 8095 ± 3266 8095 ± 3266 390 ± 240 10.0 NC
High dose 0.2 172,893 ± 72,774 172,893 ± 72,774 9961 ± 6443 10.0 NC
28 Low dose 0.1 43,036 ± 21,047 43,036 ± 21,047 988 ± 851 60.0 5.31
High dose 0.2 60,073 ± 20,639 60,073 ± 20,639 2109 ± 1464 20.0 0.347
  1. NC not calculated