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Table 1 Demographic and clinical characteristics of the study cohort

From: Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand

Characteristic at baseline Nucleoside analog regimen (n = 73) Nucleotide analog regimen (n = 29) P value
Age (years) 52.1 ± 11.3 56.6 ± 6.2 0.011*
Male sex (%) 49 (67.1 %) 24 (82.7 %) 0.114
Weight (kg) 67.8 ± 14.4 66.5 ± 14.4 0.645
Diabetes mellitus (%) 9 (12.3 %) 4 (13.8 %) 0.841
Hypertension (%) 13 (17.8 %) 11 (37.9 %) 0.031*
Cirrhosis (%) 4 (5.5 %) 3 (10.3 %) 0.381
Duration of treatment (months) 44.5 (3–105) 52.0 (3–103) 0.643
HBV e antigen positive (%) 21 (28.8 %) 11 (37.9 %) 0.364
Serum ALT concentration (U/l) 56 (15–479) 33 (13–340) 0.125
HBV DNA concentration (log IU/ml) 4.99 ± 1.73 4.86 ± 1.40 0.735
Serum creatinine concentration (mg/dl) 0.87 ± 0.18 0.84 ± 0.17 0.417
  1. Data are presented as the mean ± standard deviation, the median (range) or the number (proportion, %). *P <0.05
  2. HBV hepatitis B virus, ALT alanine transaminase