Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

Table 2 Pharmacokinetic variables of 10 mg of iv melatonin

C _max pg ml^-1	t _{1/2 elimination} min	V _d l kg^-1	CL l min^-1 kg^-1	R²	AUC _{0-∞ IV} pg ml^-1 min
389,875.0 (174,775.0–440,362.5)	39.4 (3.6)	1.2 (0.6)	0.0218 (0.0102)	0.96 (0.93–0.97)	14,179,767.6 (7,063,347.4–18,964,804.0)

Maximal concentration, coefficient of determination and area-under-the-curve data are presented as median (IQR). Elimination half-life, volume of distribution and clearance data are presented as mean (SD)
Maximal plasma concentration, C _max; elimination half-life, t _{1/2 elimination}; volume of distribution, V _d; clearance, CL; coefficient of determination, R²; area-under-the-curve, AUC

ISSN: 2050-6511