Serious (Total = 94)
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Methotrexate-Leflunomide (6.4)
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Leflunomide increases toxicity of methotrexate by pharmacodynamic synergism.
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Meloxicam-Methotrexate (5.3)
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Meloxicam increases levels of methotrexate by decreasing renal clearance.
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Clopidogrel-Omeprazole (5.3)
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Omeprazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism.
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Clopidogrel-Esomeprazole (5.3)
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Esomeprazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism.
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Atorvastatin-Vitamin B3 (5.3)
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Either increases toxicity of the other by pharmacodynamic synergism.
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Atorvastatin-Fenofibrate (5.3)
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Either increases effects of the other by pharmacodynamic synergism.
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Significant (Total = 1017)
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Aspirin-Losartan (5.5)
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Aspirin decreases effects of losartan by pharmacodynamic antagonism. losartan and aspirin both increase serum potassium.
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Losartan-Frusemide (3.2)
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Losartan increases and furosemide decreases serum potassium.
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Aspirin-Clopidogrel (3.0)
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Either increases toxicity of the other by pharmacodynamic synergism.
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Clopidogrel-Pantoprazole (2.3)
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Pantoprazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism.
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Celecoxib-Diclofenac sodium (2.0)
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Celecoxib and diclofenac both increase anticoagulation and serum potassium.
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Aspirin-Frusemide (2.0)
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Aspirin increases and furosemide decreases serum potassium.
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Minor (Total = 265)
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Glipizide - Sitagliptin (7.6)
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Either increases effects of the other by pharmacodynamic synergism.
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Metformin - Vitamin B12 (5.7)
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Metformin decreases levels of cyanocobalamin by unspecified interaction mechanism.
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Metformin-Frusemide (3.8)
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Metformin decreases levels of furosemide by unspecified interaction mechanism. Furosemide increases levels of metformin by unspecified interaction mechanism.
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Methotrexate - Folic acid (3.4)
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Folic acid decreases effects of methotrexate by pharmacodynamic antagonism.
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Aspirin-Diltiazem (2.6)
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Diltiazem increases effects of aspirin by unknown mechanism.
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Metformin-Hydrochlorothiazide (2.6)
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Hydrochlorothiazide will increase the level or effect of metformin by basic (cationic) drug competition for renal tubular clearance. Hydrochlorothiazide decreases effects of metformin by pharmacodynamic antagonism.
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