Fig. 10

Microscopic observation of liver sections stained with Masson’s Trichrome × 100. a Liver sections from control mice displayed normal cellular integrity with no fibrosis. b Liver sections from iron-overloaded mice displayed elongated fibrous septa and collagen accumulation (blue). c Desirox-treated liver section d. Liver section from the R2 mouse group with lesser blue patches. e Liver section from the R4 mouse group (f). Liver section from the R8 mouse group (g). Liver section from the S2 mouse group (h). Liver section from the S4 mouse group (i). Liver section from the S8 mouse group. MG demonstrates a nearly negligible collagen accumulation and healthy liver. Higher doses of both GA and MG demonstrate reduced collagen deposition, fibrous septum and necrotic cells in periportal veins, indicating a trend of restoration of normal cellular integrity