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Table 3 CMAP expression signature similarities between human cells treated with rapamycin and antidepressants

From: Side effect profile similarities shared between antidepressants and immune-modulators reveal potential novel targets for treating major depressive disorders

CMAP Instancea Cell Number of up-regulated probesb Number of down-regulated probesb Antidepressant with similar expression signature Antidepressant Type P-value of expression signature similarity Enrichment scorec
4431; 4445; 4466 PC3 108 112 clomipramine non-selective monoamine reuptake inhibitors 0.04844 0.627
1207; 1221; 1242 PC3 84 82 amoxapine non-selective monoamine reuptake inhibitors 0.01139 0.664
protriptyline 0.01156 0.724
maprotiline 0.01993 0.688
987; 1001; 1022 MCF7 27 56 desipramine non-selective monoamine reuptake inhibitors 0.01156 0.724
zimeldine selective serotonin reuptake inhibitors 0.00537 0.704
fluoxetine 0.03 0.661
1045; 1059; 1080 MCF7 4 182 clomipramine non-selective monoamine reuptake inhibitors 0.01017 0.732
protriptyline 0.00346 0.795
nortriptyline 0.00109 0.837
5567; 5581; 5602 MCF7 125 67 amoxapine non-selective monoamine reuptake inhibitors 0.03467 0.593
trimipramine 0.04345 0.635
nortriptyline 0.0219 0.682
6967; 6981; 7001 MCF7 44 51 clomipramine non-selective monoamine reuptake inhibitors 0.0157 0.705
protriptyline 0.02538 0.672
nortriptyline 0.0192 0.69
6927; 6940; 6958 MCF7 25 60 amitriptyline non-selective monoamine reuptake inhibitors 0.01422 0.596
  1. aThe ID of the instances from CMAP database used to generate the query expression signature for rapamycin
  2. bNumber of up and down regulated probes of the querying expression signature determined after 1.5 fold change in expression level between drug-treated cells and control cells
  3. cA measure of the enrichment of the instances for antidepressant in the list of all instances ordered by expression profile similarity score