Fig. 4

a-c Hippocampal DA, 5HT and NE (mean ± sem) for each sex, percent of WT Cu0 control mean. There was a significant (p < 0.05) main effect of sex on DA levels with females greater than males. With genotype comparisons female MTKO mice had increased DA relative to WT in females. NE (p < 0.0001) and 5HT (p < 0.005) levels. Number of rats/condition: Wildtype Cu0 males = 16, Wildtype Cu0 females = 13; Wildtype Cu10 males = 23; Wildtype Cu10 females = 13; MTKO Cu0 males = 11; MTKO Cu0 females = 19; MTKO Cu10 males = 10; MTKO Cu10 females = 15. d-e Hippocampal DA turnover (mean ± sem) for each sex, percent of WT Cu0 control mean. DA turnover was significantly decreased by Cu10 (p < 0.025) in females. Hippocampal 5HT turnover was decreased by copper in the WT (p < 0.0005) but not MTKO mice. The MTKO mice had significantly (p < 0.01) greater 5HT turnover than wildtype