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Table 1 Seven previous reports and 2 episodes of neurotoxicity and nephrotoxicity in our patient caused by combined use of lithium and risperidone

From: Neurotoxicity and nephrotoxicity caused by combined use of lithium and risperidone: a case report and literature review

R.N. Age Sex Diagnosis Risperidone dose (mg) Lithium dose (mg) Time to onseta Clinical presentation Laboratory values and Image
[3] 69 F BD 6 450 3 weeks Delirium Cr: NA; Li: 1.36
[4] 30 M BD NA 900 1 week NMS Cr: 1.6; Li: 0.6; CPK: 1428
[5] 46 M NA 3 900 2 years NMS, DKA BUN: 66
[6] 54 F BD 3 1500 2 months NMS Cr: NA; Li: 0.7; CPK: 791
[7] 60 F SD 6 NA 3 weeks Delirium EEG: Abnormal; CK: 953
[8] 75 M BD 2 900 4 days Lethargy EEG: Abnormal; Cr: NA; Li: 1.47
[9] 60 F SD 6 NA 6 days NMS EEG: Abnormal; CPK: 953
Ib 56 M SD 4.5c 900 12 days Delirium BUN/Cr: 24/1.33; Li: 1.42; CK: 975
IIb 3 600 3 days Delirium BUN/Cr: 29/1.36; Li: 1.54; CK: 90
  1. aTime is calculated from beginning the combination of lithium and risperidone to the occurrence of adverse events
  2. bI and II are serial numbers of the 2 episodes of our patient during hospitalization
  3. cIM Risperidone 25 mg/vial was prescribed 7 days before oral risperidone