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Table 1 Cellular bioavailability of MeHgCl, thiomersal and HgCl2 in PCPECs after 72 h incubation

From: Effects on and transfer across the blood-brain barrier in vitro—Comparison of organic and inorganic mercury species

 

Concentration

[μM]

Cellular Hg

[μg Hg/mg protein]

Control

0

n.d.

MeHgCl

0.01

0.010 ± 0.004

0.1

0.135 ± 0.051

1

0.807 ± 0.059

thiomersal

0.01

0.021 ± 0.002

0.1

0.084 ± 0.023

1

0.511 ± 0.107

HgCl2

0.01

0.004 ± 0.000

0.1

0.010 ± 0.002

1

0.047 ± 0.033

  1. PBCECs were cultivated in rat tail collagen-coated 24 well culture plates under the same conditions as the cells seeded on Transwell® filter inserts. Data represent mean values of at least 2 independent determinations with 2 replicates each ± SD
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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