Fig. 4

ALA/SFC improves glucose tolerance. DIO mice were orally administered ALA/SFC for 6 weeks. The numbers of mice in HFD + vehicle, HFD + ALA/SFC, and ND + vehicle groups were 5, 5, and 8, respectively. a Plasma glucose levels after 6-weeks administration of ALA/SFC. *p < 0.05, **p < 0.01 vs. vehicle-administered DIO mice (Dunnett’s test). b, c At 4th week after ALA/SFC administration, mice were fasted for 5 h and then OGTT was performed. b Fasting plasma glucose levels. c Plasma glucose levels and AUC. *p < 0.05, **p < 0.01 vs. vehicle-administered DIO mice (Dunnett’s test). d, e At 5th week of ALA/SFC administration, mice were fasted overnight and then OGTT was performed. d Fasting plasma glucose levels. e Plasma glucose levels and AUC. *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle-administered DIO mice (Dunnett’s test)