Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

Table 4 Effect of simvastatin in CHD patients with MMP-9 rs3918242 polymorphism

	week	CC (n = 188)		CT (n = 69)		TT (n = 7)
	week	Mean ± SD	% Change	Mean ± SD	% Change	Mean ± SD	% Change
TG (mmol/L)	0	1.52 ± 0.19	28.13 ± 3.	1.73 ± 0.25	28.19 ± 3.0	1.87 ± 0.27*	28.12 ± 3.22
TG (mmol/L)	12	1.11 ± 0.21	29	1.21 ± 0.18	7	1.39 ± 0.23
TC (mmol/L)	0	5.15 ± 0.61	18.24 ± 2.	5.11 ± 0.59	18.59 ± 3.0	5.12 ± 0.51	18.71 ± 3.26
TC (mmol/L)	12	4.34 ± 0.47	67	4.36 ± 0.49	6	4.37 ± 0.56
HDL-C (mmol/L)	0	1.10 ± 0.19	15.23 ± 2.	1.09 ± 0.18	14.87 ± 2.6	1.13 ± 0.21	15.61 ± 2.42
HDL-C (mmol/L)	12	1.29 ± 0.23	54	1.29 ± 0.22	1	1.29 ± 0.22	15.61 ± 2.42
LDL-C (mmol/L)	0	3.09 ± 0.26	24.23 ± 5.	3.13 ± 0.28	27.50 ± 4.4	3.38 ± 0.37*	34.53 ± 4.0
LDL-C (mmol/L)	12	2.35 ± 0.32	78	2.27 ± 0.24	4	2.10 ± 0.26*	0*
VLDL-C (mmol/L)	0	1.04 ± 0.16	34.16 ± 4.	1.01 ± 0.19	34.89 ± 4.5	1.08 ± 0.23	35.14 ± 4.6
VLDL-C (mmol/L)	12	0.79 ± 0.09	31	0.75 ± 0.11	7	0.81 ± 0.13	9
MMP-9 (ng/ml)	0	76.28 ± 21.26	24.38 ± 6.59	82.28 ± 21.26	23.10 ± 9.27	88.28 ± 22.47	22.37 ± 7.82
MMP-9 (ng/ml)	12	58.75 ± 20.21		63.75 ± 20.21		68.75 ± 20.21
TNF-α (pg/ml)	0	134.73 ± 51.38	26.48 ± 4.11	137.08 ± 55.63	25.07 ± 5.12	135.98 ± 60.12	24.46 ± 2.99
TNF-α (pg/ml)	12	100.26 ± 49.34		106.65 ± 50.04		99.65 ± 43.87
IL-10 (pg/ml)	0	100.13 ± 36.17	47.33 ± 9.28	95.08 ± 34.79	52.04 ± 11.62	103.35 ± 40.14	48.27 ± 10.56
IL-10 (pg/ml)	12	51.28 ± 26.21		47.29 ± 29.06		53.91 ± 22.38

Values are expressed as mean ± SD. *P <0.0001 compared with the CC genotype by one-way ANOVA followed with Bonferroni post-hoc test for pair-wise comparison. ^§ P <0.0001 compared with before treatment by paired student’s t-Test. HD coronary heart disease, MMP-9 matrix metalloproteinase-9, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, VLDL-C very low density lipoprotein cholesterol

ISSN: 2050-6511