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Table 1 Number of revertant colonies after POM93 exposure in absence and presence of S9 mix

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Concentration (μg/plate) Type of bacteria (mean ± SD)
TA97 TA98 TA100 TA102
A. Without S9 mix     
5000 139.7 ± 14.5 33.7 ± 5.8 162.7 ± 14.0 264.0 ± 24.4
1000 158.7 ± 29.2 36.3 ± 3.7 187.7 ± 16.6 280.0 ± 23.5
200 168.7 ± 12.0 35.7 ± 6.3 162.0 ± 9.5 290.3 ± 16.0
40 167.7 ± 9.0 41.0 ± 3.6 179.7 ± 4.5 273.7 ± 36.6
8 165.3 ± 21.2 32.7 ± 6.6 160.0 ± 22.1 297.7 ± 10.0
0 150.7 ± 5.0 33.0 ± 3.6 171.3 ± 6.8 288.7 ± 10.0
Positive control 1748.7 ± 39.5*a 2118.7 ± 94.0*b 1760.0 ± 59.7*c 1817.7 ± 24.1*d
B. With S9 mix     
5000 171.3 ± 11.7 40.7 ± 5.0 167.0 ± 38.0 284.3 ± 13.0
1000 163.3 ± 14.3 41.7 ± 2.5 155.0 ± 32.5 272.0 ± 34.0
200 184.0 ± 16.0 38.3 ± 4.0 134.3 ± 22.8 260.3 ± 15.6
40 192.7 ± 15.8 33.7 ± 3.5 160.3 ± 17.2 268.3 ± 39.8
8 175.7 ± 22.0 33.7 ± 5.0 154.3 ± 29.1 297.3 ± 9.6
0 173.0 ± 22.6 32.0 ± 5.2 173.0 ± 10.8 274.3 ± 17.4
Positive control 1690.7 ± 53.4*e 1687.7 ± 46.7*f 1184.7 ± 52.0*g 1107.3 ± 81.0*h
  1. No significant changes of revertants were observed at any concentrations of POM93 treatments in four tester strains. Statistical analysis: *P < 0.05 indicates a statistical difference with the control group by one-way ANOVA when the number of revertants was twice than control at TA97, TA98, TA100, and TA102
  2. Positive control in w/o S9 condition: a2,4,7-Trinitrofluorenone (TNF) 0.2 μg/plate; b2,4,7-Trinitrofluorenone (TNF) 0.2 μg/plate; cMethyl Methanesulfonate (MMS) 1.0 μL/plate; dMethyl Methanesulfonate (MMS) 1.0 μL/plate; e2-(2-furyl)-3-(5-nitro-2-fury)acrylamide (2-AF) 0.01 μg/plate; f2-(2-furyl)-3-(5-nitro-2-fury)acrylamide (2-AF) 0.01 μg/plate; g2-(2-furyl)-3-(5-nitro-2-fury)acrylamide (2-AF) 0.01 μg/plate; h2-aminoanthracene (2AA) 10.0 μg/plate