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Table 2 Effect of POM93 in chromosomal aberration in mice marrow cells

From: Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

     Type of chromosome aberration
  Groups No. of cells Aberration in % Chro. frag. Chro. break Chro. gap Chro. ring Chro. Asso.
Positive control Cyclophosphamide (40 mg/kg) 100 65.00 ± 2.07* 20 21 10 8 6
POM 93 2500 mg/kg 100 0.80 ± 1.03 1 3 1 2 1
1250 mg/kg 100 0.30 ± 0.48 1 1 1 0 0
625 mg/kg 100 0.60 ± 0.84 1 2 1 1 1
Negative control Solvent double distilled water (DDW) 100 0.40 ± 0.70 1 2 0 1 0
  1. The chromosomal aberrations were counted by 100 independent cells. For each treatment, at least 300 cells were examined as described in Section 2. The data are expressed as the Mean ± SD (n = 3). Significant difference between control treated group at *P < 0.05 versus control by one-way ANOVA