Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

Table 2 Effect of POM93 in chromosomal aberration in mice marrow cells

				Type of chromosome aberration
	Groups	No. of cells	Aberration in %	Chro. frag.	Chro. break	Chro. gap	Chro. ring	Chro. Asso.
Positive control	Cyclophosphamide (40 mg/kg)	100	65.00 ± 2.07*	20	21	10	8	6
POM 93	2500 mg/kg	100	0.80 ± 1.03	1	3	1	2	1
	1250 mg/kg	100	0.30 ± 0.48	1	1	1	0	0
	625 mg/kg	100	0.60 ± 0.84	1	2	1	1	1
Negative control	Solvent double distilled water (DDW)	100	0.40 ± 0.70	1	2	0	1	0

The chromosomal aberrations were counted by 100 independent cells. For each treatment, at least 300 cells were examined as described in Section 2. The data are expressed as the Mean ± SD (n = 3). Significant difference between control treated group at *P < 0.05 versus control by one-way ANOVA

ISSN: 2050-6511